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Table 2 Effect of Vitamin D3 Supplementation on PTH (pg/mL) During the Treatment (Baseline to 3 months)a

From: Reduction of parathyroid hormone with vitamin D supplementation in blacks: a randomized controlled trial

 

Vitamin D Dose, IU/d

  

Parameter, mean (SE)

Placebo

1000

2000

4000

3 months Changeb

P-Value

 n (at baseline)

62

65

64

63

  

Total PTH, pg/mL

    

−2.98 [-4.41,-1.53]

<0.0001

 Baseline PTH, mean (SE)

39.40 (14.20)

41.15 (18.02)

42.21 (20.94)

42.96 (16.79)

  

 3 months PTH, mean (SE)

43.27 (18.21)

39.83 (15.56)

36.42 (15.69)

34.18 (12.75)

  

 Difference PTHc, mean (SE)

3.93 (18.93)

−3.37 (17.84)

−6.76 (14.71)

−8.99 (12.36)

  

25(OH)D, ng/mL

      

 Baseline 25(OH)D, mean(SE)

17.07 (1.03)

17.33 (1.00)

16.12 (0.98)

17.79 (0.98)

7.57 [6.69,8.46]

<0.0001

 3 months 25(OH)D, mean (SE)

14.23 (0.96)

28.12 (1.11)

35.48 (1.21)

47.30 (1.22)

  

 Difference 25(OH)Dd, mean (SE)

−2.58 (0.66)

11.01 (1.22)

19.21 (1.21)

29.79 (1.29)

  

Calcium, mg/dL

      

 1 month Calcium, mean (SE)

9.54 (0.08)

9.77 (0.13)

9.77 (0.13)

9.81 (0.12)

  

 3 months Calcium, mean (SE)

9.57 (0.09)

9.59 (0.10)

9.59 (0.10)

9.77 (0.07)

  
  1. aPTH, Parathyroid hormone; mean (SE), mean(Standard Error); IU, international unit. The numbers do not always sum to group totals due to missing information for some variables
  2. bMonth3 – Month0 change in PTH per 1000 IU/d of vitamin D supplementation, Mean (95 % Confidence Interval). Month3 – Month0 change in 25(OH)D per 1000 IU/d of vitamin D supplementation, Mean (95 % Confidence Interval)
  3. cDifference PTH, Month 3-Month 0 difference in PTH
  4. dDifference 25(OH)D, Month 3- Month 0 difference in 25(OH)D