| |
Gene
|
NE ± SE
|
HE ± SE
|
P-value
|
|---|
|
Differentiation related genes
|
| |
PREF1
|
1.18 ± 0.14
|
1.06 ± 0.18
|
0.59
|
| |
CEBPα
|
1.06 ± 0.12
|
1.21 ± 0.16
|
0.45
|
| |
PPARγ
|
1.27 ± 0.18
|
1.16 ± 0.24
|
0.71
|
|
Proliferation related gene
|
| |
CCDN1
|
1.32 ± 0.18
|
1.09 ± 0.24
|
0.45
|
|
Inflammatory genes
|
| |
IL6
|
1.04 ± 0.08
|
0.99 ± 0.12
|
0.30
|
| |
TNFα
|
2.82 ± 0.77
|
4.02 ± 1.18
|
0.31
|
| |
IL1β
|
6.97 ± 2.35
|
11.10 ± 3.32
|
0.28
|
|
Genes involved in fatty acid and gene regulation
|
| |
FABP4
|
1.23 ± 0.22
|
1.31 ± 0.29
|
0.61
|
| |
IGF1
|
2.50 ± 0.66
|
1.25 ± 0.49
|
0.36
|
| |
IGFR1
|
0.80 ± 0.22
|
1.22 ± 0.17
|
0.10
|
| |
GHR
|
0.90 ± 0.38
|
1.56 ± 0.28
|
0.12
|
| |
GCCR
|
1.99 ± 0.48
|
1.14 ± 0.36
|
0.35
|
| |
HSD1
|
0.87 ± 0.16
|
1.20 ± 0.12
|
0.06
|
| |
SRC1
|
0.80 ± 0.19
|
1.33 ± 0.14
|
0.03*
|
| |
NCOR1
|
1.01 ± 0.17
|
1.50 ± 0.23
|
0.18
|
| |
PGC1α
|
1.62 ± 0.49
|
2.72 ± 0.69
|
0.11
|
| |
SIRT1
|
1.51 ± 0.49
|
2.77 ± 0.70
|
0.11
|
| |
SERPINE1
|
1.46 ± 0.44
|
1.67 ± 0.32
|
0.38
|
|
Wnt signaling related
|
| |
Wnt5a
|
2.35 ± 0.72
|
3.66 ± 1.02
|
0.31
|
| |
Wnt3a
|
14.14 ± 3.97
|
5.79 ± 2.96
|
0.11
|
| |
Wnt10b
|
2.3 ± 0.52
|
1.13 ± 0.39
|
0.12
|
| |
FZD1
|
3.13 ± 0.82
|
1.44 ± 0.61
|
0.15
|
| |
FZD2
|
1.89 ± 0.42
|
1.04 ± 0.31
|
0.26
|
| |
FZD7
|
1.45 ± 0.37
|
1.92 ± 0.49
|
0.43
|
| |
SFRP2
|
1.05 ± 0.30
|
2.06 ± 0.40
|
0.05*
|
| |
SFRP4
|
1.27 ± 0.25
|
1.29 ± 0.33
|
0.99
|
| |
SFRP5
|
2.85 ± 0.89
|
0.96 ± 1.16
|
0.18
|
| |
Wnt5a/SFRP5
|
7.87 ± 3.23
|
10.09 ± 4.42
|
0.31
|
|
Histone methylases related genes
|
| |
SETDB1
|
1.28 ± 0.25
|
1.04 ± 0.32
|
0.36
|
| |
SETD8
|
1.01 ± 0.25
|
1.91 ± 0.34
|
0.05*
|
- NE, gestational normal energy diet. HE, gestational High energy diet. Data are presented as least-square means ± SE. Asterisk (*) within rows indicate significant differences (P < 0.05)
