TY - JOUR AU - Denny, Gerald B. AU - Deger, Serpil M. AU - Chen, Guanhua AU - Bian, Aihua AU - Sha, Feng AU - Booker, Cindy AU - Kesler, Jaclyn T. AU - David, Sthuthi AU - Ellis, Charles D. AU - Ikizler, T. Alp PY - 2016 DA - 2016/06/03 TI - Leucine disposal rate for assessment of amino acid metabolism in maintenance hemodialysis patients JO - BMC Nutrition SP - 31 VL - 2 IS - 1 AB - Protein energy wasting (PEW) is common in patients undergoing maintenance hemodialysis (MHD) and closely associated with poor outcomes. Insulin resistance and associated alterations in amino acid metabolism are potential pathways leading to PEW. We hypothesized that the measurement of leucine disposal during a hyperinsulinemic- euglycemic-euaminoacidemic clamp (HEAC) procedure would accurately measure the sensitivity to insulin for its actions on concomitant carbohydrate and protein metabolism in MHD patients. SN - 2055-0928 UR - https://doi.org/10.1186/s40795-016-0071-9 DO - 10.1186/s40795-016-0071-9 ID - Denny2016 ER -