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Table 1 Inclusion and exclusion criteria

From: A randomized controlled trial of the effects of a prudent diet on cardiovascular risk factors, gene expression, and DNA methylation - the Diet and Genetic Intervention (DIGEST) Pilot study

Inclusion criteria
 • Willing and able to provide informed consent
 • Willing and able to attend 3 clinic visits
 • Willing and able to eat all foods on Prudent or Western diets
 • Age ≥18 years of age
Exclusion criteria (self reported)
 • Alcoholic beverage intake >14 drinks/week
 • Use of food or nutritional supplements that cannot be discontinued
 • Current use of anti-inflammatory medications that cannot be discontinued
 • Current use of anti-hypertensive medications that cannot be discontinued
 • Current use of anti-cholesterol medications that cannot be discontinued
 • Previous diagnosis of cardiovascular disease or cardiovascular event within past year
 • Body-mass-index ≥45 kg/m2
 • High blood pressure (or on anti-hypertensive medications)
 • Abnormal blood lipids (or on lipid-modifying medications)
 • Diabetes mellitus (FPG ≥ 7.0) or impaired fasting glucose (fasting glucose 6.1 to 6.9)
 • Renal insufficiency or disease
 • Hepatitis or Jaundice
 • Liver disease
 • Tuberculosis
 • HIV/AIDS
 • Active malignancy or cancer treatment within past 1 year
 • Inflammatory bowel disease, malabsorptive states
 • Current asthma (use of bronchodilator ≥1 time in past month)
 • Any chronic disease likely to influence adherence to diet or participation in study
 • Current or planned pregnancy during term of study
 • Current use of oral contraceptives or hormone replacement therapy