Table 2 Comparison of total 25(OH)D, free and diplotype-corrected free 25(OH)D, and PTH and DBP concentrations among the GC diplotypes
GC diplotypes | GC1S/1S | GC 1S/2 | GC 1S/1 F | GC 1 F/1 F | GC 1 F/2 | GC 2/2 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dependent variable | ANCOVA p-value | ||||||||||||||||||
S-25(OH)D (nmol/L) | 55.9 (280) | ± | 0.99 | 51.9 (152) | ± | 1.34 | 50.2 (13) | ± | 4.6 | 55.1 (38) | ± | 2.7 | 58.6 (90) | ± | 1.7 | 52.5 (26) | ± | 3.3 | 0.033 a |
Free 25(OH)D (pmol/L) | 12.2 (236) | ± | 0.29 | 11.7 (121) | ± | 0.40 | 10.1 (10) | ± | 1.40 | 11.6 (31) | ± | 0.80 | 12.5 (78) | ± | 0.50 | 12.6 (24) | ± | 0.90 | 0.491a |
Diplotype corrected free 25(OH)D (pmol/L)d | 14.1 (236) | ± | 0.30 | 6.06 (121) | ± | 0.42 | 6.40 (10) | ± | 1.47 | 9.65 (31) | ± | 0.85 | 12.2 (78) | ± | 0.53 | 23.1 (24) | ± | 0.95 | <0.001a |
Bioavailable 25(OH)D (nmol/L) | 4.81 (236) | ± | 0.12 | 4.70 (121) | ± | 0.16 | 3.97 (10) | ± | 0.57 | 4.62 (31) | ± | 0.33 | 5.01 (78) | ± | 0.20 | 5.07 (24) | ± | 0.37 | 0.469a |
Diplotype corrected bioavailable 25(OH)D (nmol/L)d | 5.60 (235) | ± | 0.13 | 2.44 (121) | ± | 0.17 | 2.50 (10) | ± | 0.60 | 3.86 (31) | ± | 0.35 | 4.92 (78) | ± | 0.22 | 9.25 (24) | ± | 0.39 | <0.001 a |
S-DBP (mg/L) | 369 (238) | ± | 5.55 | 360 (121) | ± | 7.78 | 364 (10) | ± | 27.1 | 388(31) | ± | 15.4 | 380 (78) | ± | 9.7 | 321 (24) | ± | 17.5 | 0.039 b |
S-PTH (ng/L) | 55.0 (289) | ± | 1.44 | 56.8 (157) | ± | 1.96 | 60.6 (13) | ± | 6.78 | 45.6 (38) | ± | 3.96 | 57.5 (92) | ± | 2.55 | 46.0 (26) | ± | 4.79 | 0.040 c |