Protocol for the EMPHASIS study; epigenetic mechanisms linking maternal pre-conceptional nutrition and children’s health in India and Sub-Saharan Africa

Table 3 Genes not on the EPIC array with previous evidence of associations with nutritional exposures and/or phenotypes

Locus	Genomic location	Associated exposures / outcomes	Refs
PAX8	chr2:113,992,866–113,993,036	Peri-conceptional nutrition exposure	[15]
POMC	chr2:25,384,508–25,384,832	Peri-conceptional nutrition exposure + phenotypic effect	[19]
HES1	chr3:193,849,141–193,849,361	Phenotypic effect	[42]
PPARGC1A	chr4: 23,892,404-23,892,571	Maternal BMI exposure	[13]
RBM46	chr4:155,702,818–155,703,110	Peri-conceptional nutrition exposure	[16]
NOS3	chr7:150,684,570–150,684,745	Phenotypic effect	[12, 43]
VIPR2	chr7:158,905,218–158,905,477	Famine exposure + phenotypic effect	[44, 45]
RXRA	chr9:137,215,689–137,215,826; chr9:137,215,979–137,216,126	Late gestation nutrition exposure + phenotypic effect	[12, 46]
H19	chr11:2,024,197–2,024,341	Peri-conceptional nutrition exposure	[47]
IGF2	chr11:2,169,457–2,169,541; chr11:2,169,617–2,169,751	Peri-conceptional nutrition exposure	[24, 48, 49]
MEG3 (GTL2)	chr14:101,294,220–101,294,391	Peri-conceptional nutrition exposure + phenotypic effect	[50]

ISSN: 2055-0928