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Table 3 Genes not on the EPIC array with previous evidence of associations with nutritional exposures and/or phenotypes

From: Protocol for the EMPHASIS study; epigenetic mechanisms linking maternal pre-conceptional nutrition and children’s health in India and Sub-Saharan Africa

Locus Genomic location Associated exposures / outcomes Refs
PAX8 chr2:113,992,866–113,993,036 Peri-conceptional nutrition exposure [15]
POMC chr2:25,384,508–25,384,832 Peri-conceptional nutrition exposure + phenotypic effect [19]
HES1 chr3:193,849,141–193,849,361 Phenotypic effect [42]
PPARGC1A chr4: 23,892,404-23,892,571 Maternal BMI exposure [13]
RBM46 chr4:155,702,818–155,703,110 Peri-conceptional nutrition exposure [16]
NOS3 chr7:150,684,570–150,684,745 Phenotypic effect [12, 43]
VIPR2 chr7:158,905,218–158,905,477 Famine exposure + phenotypic effect [44, 45]
RXRA chr9:137,215,689–137,215,826; chr9:137,215,979–137,216,126 Late gestation nutrition exposure + phenotypic effect [12, 46]
H19 chr11:2,024,197–2,024,341 Peri-conceptional nutrition exposure [47]
IGF2 chr11:2,169,457–2,169,541; chr11:2,169,617–2,169,751 Peri-conceptional nutrition exposure [24, 48, 49]
MEG3 (GTL2) chr14:101,294,220–101,294,391 Peri-conceptional nutrition exposure + phenotypic effect [50]