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Table 1 General characteristics of the studies included

From: Impact of vitamin D supplementation on C-reactive protein; a systematic review and meta-analysis of randomized controlled trials

Author, year of publication Country Study design Status Sample size Sex (% of women) Mean age Intervention Supplemented the dose of vitamin D (IU/day) Follow-up duration
A Sadiya (47), 2015 UAE randomized double-blind clinical trial vitamin D-deficient obese, type 2 diabetic 87 Male and Female (70%) 49 ± 8 cholecalciferol
(vitamin D3)
phase 1; 6000
phase 2; 3000
6 month
A. Breslavsky (48), 2013 Israel randomized, placebo-controlled type 2 diabetes mellitus 47 Male and Female (53.1%) 66.8 ± 9.2 cholecalciferol
(vitamin D3)
1000 12 month
Claudia Gagnon [34], 2014 Australia randomized, placebo-controlled trial vitamin D-deficient and at risk of type 2 diabetes 95 Male and Female (71%) 54 years cholecalciferol
(vitamin D3)
2000–6000 6 month
Edgar Turner Overton [33], 2015 USA randomized, double-blind, placebo-controlled HIV-infected 167 Male and Female (9%) 36 years cholecalciferol
(vitamin D3)
4000 48-week
Gavin Dreyer [30], 2014 UK randomised controlled trial non-diabetic chronic kidney disease stage 3–4 and concomitant vitamin D deficiency 38 Male and Female (39.1%) 45.8 (10.0) ergocalciferol 50,000 6 month
Indrani Sinha-Hikim [25], 2015 USA randomized pre-diabetes and hypovitaminosis D 80 Male and Female (70%) 52.0 years cholecalciferol
(vitamin D3)
85,300 IU ± 16,000 12 month
Isa Gabriela de Medeiros Cavalcante [29], 2015 Brazil double blind, randomized, placebo-controlled trial With vitamin D insufficiency 40 Female (100%) 68 ± 6 cholecalciferol
(vitamin D3)
200,000 4 week
Julia Åivo (49), 2015 Finland double-blind, randomized, parallel   59 Male and Female (62.7%) 38 (22–53) cholecalciferol
(vitamin D3)
20,000 12 month
L. Wamberg (50), 2013 Denmark double-blind design   52 Male and Female (71%) 18 to 50 years cholecalciferol
(vitamin D3)
7000  
M.D. Witham (51), 2015 UK Parallel-group, double-blind, randomised placebo-controlled trial with chronic fatigue syndrome 50 Male and Female (52%) 49 ± 13 cholecalciferol
(vitamin D3)
100,000 6 month
M.P. BJORKMAN [28], 2009 Finland randomised double-blind placebo controlled trial chronically impaired mobility 218 Male and Female 84.5 ± 7.5 cholecalciferol
(vitamin D3)
0
400
1200
6 month
Nafiseh Toghianifar (52), 2015 Iran double blind randomized clinical trial with a diagnosis of relapsing remitting multiple sclerosis (RRMS) 94 Male and Female (84.2%) 31.50 ± 7.60 cholecalciferol
(vitamin D3)
50,000 12 week
Nasrin Sharifi (53), 2014 Iran parallel, double-blind, placebo-controlled non-alcoholic fatty liver disease (NAFLD) 53 Male and Female (51%) 40.33 ± 8.65 cholecalciferol
(vitamin D3)
50,000 4 month
Ohk-Hyun Ryu [32], 2014 Korea prospective, randomized, double-blinded, placebo-controlled trial type 2 diabetic patients 62 Male and Female 54.5 ± 7.4 cholecalciferol
(vitamin D3)
2000 24 week
Pamela R. von Hurst (54), 2010 New Zealand randomised, placebo-controlled trial   81 Female (100%) 45.5 cholecalciferol
(vitamin D3)
4000 6 month
Paulette D. Chandler (55), 2014 USA Randomized, Placebo-Controlled Trial   328 Male and Female (67.7%) 51 cholecalciferol
(vitamin D3)
1000
2000
4000
3 month
Rahaimi (56), 2013 Iran randomised, placebo-controlled, double-blinded trial With vitamin D deficiency 50 Female (100%) 30 cholecalciferol
(vitamin D3)
50,000 2 month
Rolf Jorde (57), 2010 Norway Randomized overweight and obese 437 Male and Female (64.3%) 47 cholecalciferol
(vitamin D3)
40,000 12 month
Seth I Sokol [31], 2012 USA double-blind placebo wait-list control design with CAD and vitamin D deficiency 90 Male and Female (26.5%) 55 ± 9.6 ergocalciferol 50,000 12 week
Tina K. Thethi, 2015 USA double blind, randomized, placebo-controlled trial with type 2 diabetes and chronic kidney disease 55 Male and Female (32.7%) 63 Paricalcitol 1 mcg 3 month
Tyler Barker (58), 2015 USA randomized, double blind, placebo-controlled   56 Male and Female (32.7%) 32(7) cholecalciferol
(vitamin D3)
4000
8000
5 week
Ulla Kampmann (59), 2014 Denmark double-blind, randomized, placebo-controlled trial with type 2 diabetes and hypovitaminosis D 15 Male and Female (46.6%) 59.3 ± 4.4 cholecalciferol
(vitamin D3)
5600
11,200
12 week
Zatollah Asemi (60), 2013 Iran randomized, double-blind, placebo-controlled clinical healthy pregnant women 48 Female (100%) 29 cholecalciferol
(vitamin D3)
400 25 week