Skip to main content
# Table 3 Associations between SNPs and LDL-C concentration in a cross-sectional study and a seasonal variation study

Gene/season | rs ID/season | CHR | Position | Alleles^{a} | MAF | Genotype^{b} | P_{HWE} | Complete case dataset^{c} | Observed subject dataset^{d} | Multiple imputation dataset (m = 100)^{e} | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|

AA | Aa | aa | β | S.E. | P | β | S.E. | P | β | S.E. | P | |||||||

Cross-sectional study^{f} | ||||||||||||||||||

Number of observations (person · season) | 51 | 72 | 78 | |||||||||||||||

PSRC1 | rs599839 | 1 | 109279544 | A>G | 0.08 | 66 | 11 | 1 | 0.79 | -7.1 × E-2 | 4.0 × E-2 | 0.08 | -8.6 × E-2 | 3.5 × E-2 | 0.01 | -8.0 × E-2 | 3.4 × E-2 | 0.02 |

HMGCR | rs12654264 | 5 | 75352778 | T>A | 0.44 | 25 | 38 | 15 | 1.00 | 3.5 × E-2 | 3.7 × E-2 | 0.35 | 2.1 × E-2 | 2.9 × E-2 | 0.47 | 2.3 × E-2 | 2.7 × E-2 | 0.40 |

TIMD4 | rs6882076 | 5 | 156963286 | C>T | 0.15 | 56 | 21 | 1 | 0.82 | -1.9 × E-2 | 3.7 × E-2 | 0.61 | 2.2 × E-2 | 2.8 × E-2 | 0.44 | 1.9 × E-2 | 2.7 × E-2 | 0.50 |

TBL2 | rs17145738 | 7 | 73568544 | C>T | 0.11 | 62 | 15 | 1 | 1.00 | -5.1 × E-2 | 3.6 × E-2 | 0.17 | -5.5 × E-2 | 2.9 × E-2 | 0.06 | -5.1 × E-2 | 2.9 × E-2 | 0.09 |

- | rs651007 | 9 | 133278431 | C>T | 0.28 | 37 | 39 | 2 | 0.08 | 5.6 × E-2 | 3.0 × E-2 | 0.06 | 4.8 × E-2 | 2.4 × E-2 | 0.05 | 4.8 × E-2 | 2.4 × E-2 | 0.05 |

TOMM40 | rs1160985 | 19 | 44900155 | C>T | 0.35 | 32 | 38 | 8 | 0.80 | -5.3 × E-2 | 3.2 × E-2 | 0.11 | -6.4 × E-2 | 2.6 × E-2 | 0.01 | -6.7 × E-2 | 2.5 × E-2 | 0.009 |

APOC1 | rs445925 | 19 | 44912383 | G>A | 0.10 | 64 | 12 | 2 | 0.35 | -2.0 × E-2 | 4.8 × E-2 | 0.68 | -5.9 × E-2 | 3.3 × E-2 | 0.08 | -5.8 × E-2 | 3.2 × E-2 | 0.07 |

Seasonal variation research^{g} | ||||||||||||||||||

Number of observations (person · season) | 204 | 262 | 312 | |||||||||||||||

PSRC1 | rs599839 | -4.8 × E-2 | 3.6 × E-2 | 0.19 | -4.8 × E-2 | 3.1 × E-2 | 0.12 | -4.7 × E-2 | 3.2 × E-2 | 0.15 | ||||||||

Season | - Winter | Reference | Reference | Reference | ||||||||||||||

- Spring | -1.5 × E-2 | 8.9 × E-3 | 0.11 | -1.7 × E-2 | 7.8 × E-3 | 0.03 | -1.6 × E-2 | 1.1 × E-2 | 0.13 | |||||||||

- Summer | -2.8 × E-2 | 8.9 × E-3 | 0.002 | -2.4 × E-2 | 7.7 × E-3 | 0.002 | -2.2 × E-2 | 1.1 × E-2 | 0.04 | |||||||||

- Autumn | -1.4 × E-2 | 9.0 × E-3 | 0.12 | -1.5 × E-2 | 8.2 × E-3 | 0.08 | -1.1 × E-2 | 1.1 × E-2 | 0.34 | |||||||||

HMGCR | rs12654264 | 3.9 × E-2 | 3.3 × E-2 | 0.24 | 2.6 × E-2 | 2.4 × E-2 | 0.28 | 2.5 × E-2 | 2.6 × E-2 | 0.33 | ||||||||

Season | - Winter | Reference | Reference | Reference | ||||||||||||||

- Spring | -1.4 × E-2 | 8.9 × E-3 | 0.11 | -1.7 × E-2 | 7.8 × E-3 | 0.03 | -1.6 × E-2 | 1.1 × E-2 | 0.13 | |||||||||

- Summer | -2.8 × E-2 | 8.9 × E-3 | 0.002 | -2.4 × E-2 | 7.7 × E-3 | 0.002 | -2.2 × E-2 | 1.1 × E-2 | 0.04 | |||||||||

- Autumn | -1.4 × E-2 | 9.0 × E-3 | 0.12 | -1.5 × E-2 | 8.2 × E-3 | 0.07 | -1.1 × E-2 | 1.1 × E-2 | 0.34 | |||||||||

TIMD4 | rs6882076 | 6.5 × E-3 | 3.2 × E-2 | 0.84 | 1.8 × E-2 | 2.4 × E-2 | 0.45 | 1.9 × E-2 | 2.6 × E-2 | 0.47 | ||||||||

Season | - Winter | Reference | Reference | Reference | ||||||||||||||

- Spring | -1.4 × E-2 | 8.9 × E-3 | 0.11 | -1.7 × E-2 | 7.8 × E-3 | 0.03 | -1.6 × E-2 | 1.1 × E-2 | 0.13 | |||||||||

- Summer | -2.8 × E-2 | 8.9 × E-3 | 0.002 | -2.4 × E-2 | 7.7 × E-3 | 0.002 | -2.2 × E-2 | 1.1 × E-2 | 0.04 | |||||||||

- Autumn | -1.4 × E-2 | 9.0 × E-3 | 0.12 | -1.5 × E-2 | 8.2 × E-3 | 0.07 | -1.1 × E-2 | 1.1 × E-2 | 0.34 | |||||||||

TBL2 | rs17145738 | -4.6 × E-2 | 3.2 × E-2 | 0.16 | -4.8 × E-2 | 2.6 × E-2 | 0.08 | -4.7 × E-2 | 2.8 × E-2 | 0.09 | ||||||||

Season | - Winter | Reference | Reference | Reference | ||||||||||||||

- Spring | -1.4 × E-2 | 8.9 × E-3 | 0.11 | -1.7 × E-2 | 7.8 × E-3 | 0.03 | -1.6 × E-2 | 1.1 × E-2 | 0.13 | |||||||||

- Summer | -2.8 × E-2 | 8.9 × E-3 | 0.002 | -2.4 × E-2 | 7.7 × E-3 | 0.002 | -2.2 × E-2 | 1.1 × E-2 | 0.04 | |||||||||

- Autumn | -1.4 × E-2 | 9.0 × E-3 | 0.12 | -1.5 × E-2 | 8.2 × E-3 | 0.08 | -1.1 × E-2 | 1.1 × E-2 | 0.34 | |||||||||

- | rs651007 | 5.0 × E-2 | 2.7 × E-2 | 0.07 | 4.7 × E-2 | 2.1 × E-2 | 0.03 | 4.7 × E-2 | 2.3 × E-2 | 0.04 | ||||||||

Season | - Winter | Reference | Reference | Reference | ||||||||||||||

- Spring | -1.4 × E-2 | 9.0 × E-3 | 0.11 | -1.7 × E-2 | 7.8 × E-3 | 0.03 | -1.6 × E-2 | 1.1 × E-2 | 0.13 | |||||||||

- Summer | -2.8 × E-2 | 8.9 × E-3 | 0.002 | -2.4 × E-2 | 7.7 × E-3 | 0.002 | -2.2 × E-2 | 1.1 × E-2 | 0.04 | |||||||||

- Autumn | -1.4 × E-2 | 9.0 × E-3 | 0.11 | -1.5 × E-2 | 8.2 × E-3 | 0.07 | -1.1 × E-2 | 1.1 × E-2 | 0.34 | |||||||||

TOMM40 | rs1160985 | -4.7 × E-2 | 2.8 × E-2 | 0.11 | -5.9 × E-2 | 2.2 × E-2 | 0.01 | -5.9 × E-2 | 2.4 × E-2 | 0.01 | ||||||||

Season | - Winter | Reference | Reference | Reference | ||||||||||||||

- Spring | -1.4 × E-2 | 9.0 × E-3 | 0.11 | -1.6 × E-2 | 7.8 × E-3 | 0.04 | -1.6 × E-2 | 1.1 × E-2 | 0.13 | |||||||||

- Summer | -2.8 × E-2 | 8.9 × E-3 | 0.002 | -2.4 × E-2 | 7.8 × E-3 | 0.002 | -2.2 × E-2 | 1.1 × E-2 | 0.04 | |||||||||

- Autumn | -1.4 × E-2 | 9.0 × E-3 | 0.12 | -1.5 × E-2 | 8.2 × E-3 | 0.07 | -1.1 × E-2 | 1.1 × E-2 | 0.33 | |||||||||

APOC1 | rs445925 | -1.4 × E-2 | 4.3 × E-2 | 0.74 | -4.9 × E-2 | 2.8 × E-2 | 0.08 | -4.9 × E-2 | 3.0 × E-2 | 0.11 | ||||||||

Season | - Winter | Reference | Reference | Reference | ||||||||||||||

- Spring | -1.5 × E-2 | 8.9 × E-3 | 0.11 | -1.7 × E-2 | 7.8 × E-3 | 0.03 | -1.6 × E-2 | 1.1 × E-2 | 0.13 | |||||||||

- Summer | -2.8 × E-2 | 8.9 × E-3 | 0.002 | -2.4 × E-2 | 7.7 × E-3 | 0.002 | -2.2 × E-2 | 1.1 × E-2 | 0.04 | |||||||||

- Autumn | -1.4 × E-2 | 9.0 × E-3 | 0.12 | -1.5 × E-2 | 8.2 × E-3 | 0.07 | -1.1 × E-2 | 1.1 × E-2 | 0.34 |