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# Table 4 Associations among nutrient intake and SNPs on LDL-C concentration according to three dietary assessment methods

Complete case dataset^{a} | Observed subject dataset^{b} | Multiple imputation dataset (m = 100)^{c} | |||||||
---|---|---|---|---|---|---|---|---|---|

β | S.E. | P | β | S.E. | P | β | S.E. | P | |

Cross-sectional study | |||||||||

FFQ (one year)^{d} | |||||||||

Number of observations (person · season) | 51 | 73 | 78 | ||||||

Cholesterol (mg/MJ) | 4.5 × E-2 | 1.8 × E-1 | 0.81 | 2.4 × E-2 | 1.4 × E-1 | 0.87 | 3.3 × E-2 | 1.4 × E-1 | 0.81 |

PSRC1 rs599839 | 9.7 × E-2 | 5.0 × E-1 | 0.85 | 2.3 × E-2 | 4.6 × E-1 | 0.96 | 3.7 × E-2 | 4.5 × E-1 | 0.94 |

Interaction | -1.1 × E-1 | 3.4 × E-1 | 0.74 | -7.0 × E-2 | 3.1 × E-1 | 0.82 | -7.7 × E-2 | 3.1 × E-1 | 0.80 |

Cholesterol (mg/MJ) | 1.5 × E-2 | 2.0 × E-1 | 0.94 | -3.1 × E-2 | 1.6 × E-1 | 0.85 | -2.4 × E-2 | 1.5 × E-1 | 0.87 |

TIMD4 rs6882076 | -2.0 × E-1 | 4.6 × E-1 | 0.67 | -8.1 × E-2 | 4.0 × E-1 | 0.84 | -1.0 × E-1 | 4.0 × E-1 | 0.79 |

Interaction | 1.2 × E-1 | 3.0 × E-1 | 0.70 | 7.0 × E-2 | 2.6 × E-1 | 0.79 | 8.1 × E-2 | 2.6 × E-1 | 0.75 |

TDF (g/MJ) | -1.7 × E-1 | 2.6 × E-1 | 0.53 | -1.3 × E-1 | 2.3 × E-1 | 0.56 | -8.4 × E-2 | 2.2 × E-1 | 0.70 |

- rs651007 | 3.5 × E-2 | 5.3 × E-2 | 0.51 | 1.5 × E-2 | 4.6 × E-2 | 0.75 | 2.5 × E-2 | 4.4 × E-2 | 0.57 |

Interaction | 1.6 × E-1 | 2.9 × E-1 | 0.59 | 2.1 × E-1 | 2.6 × E-1 | 0.40 | 1.6 × E-1 | 2.5 × E-1 | 0.52 |

TDF (g/MJ) | -2.0 × E-1 | 2.1 × E-1 | 0.35 | -9.8 × E-2 | 1.7 × E-1 | 0.57 | -9.8 × E-2 | 1.7 × E-1 | 0.57 |

TOMM40 rs1160985 | -1.1 × E-1 | 5.5 × E-2 | 0.05 | -1.2 × E-1 | 4.4 × E-2 | 0.008 | -1.2 × E-1 | 4.3 × E-2 | 0.007 |

Interaction | 2.8 × E-1 | 2.8 × E-1 | 0.32 | 3.0 × E-1 | 2.3 × E-1 | 0.20 | 3.0 × E-1 | 2.3 × E-1 | 0.18 |

Ethanol (g/day) | -8.5 × E-2 | 2.9 × E-2 | 0.006 | -3.7 × E-2 | 2.3 × E-2 | 0.11 | -3.3 × E-2 | 2.3 × E-2 | 0.16 |

TBL2 rs17145738 | -9.3 × E-2 | 5.1 × E-2 | 0.07 | -5.4 × E-2 | 4.4 × E-2 | 0.23 | -4.7 × E-2 | 4.5 × E-2 | 0.30 |

Interaction | 3.1 × E-2 | 4.8 × E-2 | 0.52 | -8.6 × E-3 | 4.3 × E-2 | 0.84 | -1.3 × E-2 | 4.3 × E-2 | 0.77 |

First season 3-day WDRs^{d} | |||||||||

Number of observations (person · season) | 51 | 72 | 78 | ||||||

Cholesterol (mg/MJ) | 1.7 × E-2 | 1.3 × E-1 | 0.90 | -6.7 × E-2 | 9.2 × E-2 | 0.47 | -6.0 × E-2 | 8.8 × E-2 | 0.50 |

PSRC1 rs599839 | -1.1 × E+0 | 5.5 × E-1 | 0.04 | -8.6 × E-1 | 3.8 × E-1 | 0.03 | -8.4 × E-1 | 3.7 × E-1 | 0.03 |

Interaction | 6.8 × E-1 | 3.5 × E-1 | 0.06 | 5.0 × E-1 | 2.4 × E-1 | 0.04 | 4.9 × E-1 | 2.4 × E-1 | 0.05 |

Cholesterol (mg/MJ) | 1.3 × E-2 | 1.7 × E-1 | 0.94 | -9.4 × E-3 | 1.1 × E-1 | 0.93 | -5.4 × E-3 | 1.0 × E-1 | 0.96 |

TIMD4 rs6882076 | -2.3 × E-1 | 4.0 × E-1 | 0.57 | 2.5 × E-2 | 3.1 × E-1 | 0.94 | 6.0 × E-2 | 3.1 × E-1 | 0.85 |

Interaction | 1.4 × E-1 | 2.6 × E-1 | 0.60 | -3.4 × E-3 | 2.0 × E-1 | 0.99 | -2.7 × E-2 | 2.0 × E-1 | 0.89 |

TDF (g/MJ) | -2.6 × E-1 | 1.4 × E-1 | 0.07 | -1.9 × E-1 | 1.3 × E-1 | 0.14 | -1.4 × E-1 | 1.3 × E-1 | 0.26 |

- rs651007 | 6.8 × E-2 | 5.6 × E-2 | 0.23 | 1.1 × E-2 | 4.5 × E-2 | 0.82 | 2.3 × E-2 | 4.5 × E-2 | 0.61 |

Interaction | -7.6 × E-2 | 2.0 × E-1 | 0.71 | 1.5 × E-1 | 1.7 × E-1 | 0.37 | 9.6 × E-2 | 1.7 × E-1 | 0.56 |

TDF (g/MJ) | -2.7 × E-1 | 2.0 × E-1 | 0.19 | -7.1 × E-2 | 1.3 × E-1 | 0.58 | -6.9 × E-2 | 1.3 × E-1 | 0.58 |

TOMM40 rs1160985 | -3.9 × E-2 | 6.4 × E-2 | 0.55 | -4.8 × E-2 | 4.7 × E-2 | 0.32 | -6.1 × E-2 | 4.6 × E-2 | 0.19 |

Interaction | -1.1 × E-2 | 2.2 × E-1 | 0.96 | -3.3 × E-2 | 1.7 × E-1 | 0.84 | -1.0 × E-2 | 1.6 × E-1 | 0.95 |

Ethanol (g/day) | -7.7 × E-2 | 3.4 × E-2 | 0.03 | -6.3 × E-2 | 2.5 × E-2 | 0.02 | -5.1 × E-2 | 2.5 × E-2 | 0.05 |

TBL2 rs17145738 | -6.6 × E-2 | 5.5 × E-2 | 0.24 | -6.8 × E-2 | 4.7 × E-2 | 0.15 | -6.3 × E-2 | 4.6 × E-2 | 0.18 |

Interaction | 2.5 × E-2 | 7.0 × E-2 | 0.72 | 2.2 × E-2 | 6.4 × E-2 | 0.73 | 1.6 × E-2 | 6.3 × E-2 | 0.80 |

Seasonal variation research | |||||||||

Four season 3-day WDRs^{e} | |||||||||

Number of observations (person · season) | 204 | 262 | 312 | ||||||

Cholesterol (mg/MJ) | 5.6 × E-2 | 3.2 × E-2 | 0.08 | 3.7 × E-2 | 2.7 × E-2 | 0.18 | 3.2 × E-2 | 4.3 × E-2 | 0.46 |

PSRC1 rs599839 | -2.9 × E-1 | 1.5 × E-1 | 0.05 | -2.9 × E-1 | 1.3 × E-1 | 0.02 | -2.9 × E-1 | 1.6 × E-1 | 0.07 |

Interaction | 1.5 × E-1 | 8.9 × E-2 | 0.10 | 1.5 × E-1 | 7.7 × E-2 | 0.05 | 1.5 × E-1 | 1.0 × E-1 | 0.12 |

Season - Winter | Reference | Reference | Reference | ||||||

- Spring | -1.8 × E-2 | 9.0 × E-3 | 0.05 | -1.9 × E-2 | 7.7 × E-3 | 0.01 | -2.0 × E-2 | 1.1 × E-2 | 0.06 |

- Summer | -2.9 × E-2 | 9.0 × E-3 | 0.001 | -2.6 × E-2 | 7.7 × E-3 | <0.001 | -2.5 × E-2 | 1.1 × E-2 | 0.02 |

- Autumn | -1.9 × E-2 | 9.0 × E-3 | 0.04 | -1.8 × E-2 | 8.2 × E-3 | 0.03 | -1.5 × E-2 | 1.1 × E-2 | 0.18 |

Cholesterol (mg/MJ) | 3.8 × E-2 | 3.6 × E-2 | 0.29 | 2.9 × E-2 | 3.0 × E-2 | 0.34 | 2.4 × E-2 | 4.7 × E-2 | 0.60 |

TIMD4 rs6882076 | -1.8 × E-1 | 1.1 × E-1 | 0.09 | -1.3 × E-1 | 9.4 × E-2 | 0.18 | -9.9 × E-2 | 1.2 × E-1 | 0.42 |

Interaction | 1.2 × E-1 | 6.6 × E-2 | 0.07 | 9.2 × E-2 | 5.8 × E-2 | 0.12 | 7.5 × E-2 | 7.7 × E-2 | 0.33 |

Season - winter | Reference | Reference | Reference | ||||||

- spring | -1.7 × E-2 | 9.0 × E-3 | 0.07 | -1.8 × E-2 | 7.7 × E-3 | 0.02 | -1.9 × E-2 | 1.0 × E-2 | 0.08 |

- summer | -3.1 × E-2 | 9.0 × E-3 | <0.001 | -2.7 × E-2 | 7.7 × E-3 | <0.001 | -2.5 × E-2 | 1.1 × E-2 | 0.02 |

- autumn | -1.9 × E-2 | 9.0 × E-3 | 0.04 | -1.8 × E-2 | 8.2 × E-3 | 0.03 | -1.5 × E-2 | 1.1 × E-2 | 0.19 |

TDF (g/MJ) | 3.1 × E-2 | 4.2 × E-2 | 0.46 | 1.8 × E-2 | 3.9 × E-2 | 0.64 | 7.0 × E-3 | 5.4 × E-2 | 0.90 |

- rs651007 | 7.3 × E-2 | 3.1 × E-2 | 0.02 | 6.8 × E-2 | 2.5 × E-2 | 0.007 | 6.3 × E-2 | 2.8 × E-2 | 0.03 |

Interaction | -9.4 × E-2 | 6.5 × E-2 | 0.15 | -8.9 × E-2 | 5.7 × E-2 | 0.12 | -6.3 × E-2 | 7.5 × E-2 | 0.40 |

Season - winter | Reference | Reference | Reference | ||||||

- spring | -1.5 × E-2 | 9.1 × E-3 | 0.10 | -1.7 × E-2 | 7.8 × E-3 | 0.03 | -1.8 × E-2 | 1.1 × E-2 | 0.09 |

- summer | -2.9 × E-2 | 9.2 × E-3 | 0.002 | -2.6 × E-2 | 7.9 × E-3 | <0.001 | -2.4 × E-2 | 1.1 × E-2 | 0.03 |

- autumn | -1.5 × E-2 | 9.0 × E-3 | 0.11 | -1.5 × E-2 | 8.2 × E-3 | 0.07 | -1.2 × E-2 | 1.1 × E-2 | 0.27 |

TDF (g/MJ) | -4.7 × E-2 | 6.6 × E-2 | 0.47 | -7.5 × E-2 | 5.4 × E-2 | 0.17 | -5.5 × E-2 | 8.0 × E-2 | 0.49 |

TOMM40 rs1160985 | -6.0 × E-2 | 3.3 × E-2 | 0.07 | -7.5 × E-2 | 2.6 × E-2 | 0.005 | -7.0 × E-2 | 3.1 × E-2 | 0.03 |

Interaction | 5.8 × E-2 | 7.5 × E-2 | 0.44 | 8.1 × E-2 | 6.3 × E-2 | 0.20 | 5.8 × E-2 | 8.7 × E-2 | 0.50 |

Season - winter | Reference | Reference | Reference | ||||||

- spring | -1.6 × E-2 | 9.4 × E-3 | 0.10 | -1.8 × E-2 | 7.9 × E-3 | 0.03 | -1.8 × E-2 | 1.1 × E-2 | 0.09 |

- summer | -2.9 × E-2 | 9.4 × E-3 | 0.002 | -2.6 × E-2 | 7.9 × E-3 | 0.001 | -2.4 × E-2 | 1.1 × E-2 | 0.03 |

- autumn | -1.5 × E-2 | 9.2 × E-3 | 0.10 | -1.6 × E-2 | 8.3 × E-3 | 0.06 | -1.3 × E-2 | 1.1 × E-2 | 0.24 |

Ethanol (g/day) | -3.0 × E-2 | 1.5 × E-2 | 0.05 | -2.9 × E-2 | 1.2 × E-2 | 0.01 | -3.6 × E-2 | 1.7 × E-2 | 0.03 |

TBL2 rs17145738 | -7.0 × E-2 | 3.7 × E-2 | 0.06 | -7.3 × E-2 | 2.9 × E-2 | 0.02 | -6.9 × E-2 | 3.3 × E-2 | 0.04 |

Interaction | 4.3 × E-2 | 3.0 × E-2 | 0.15 | 4.7 × E-2 | 2.4 × E-2 | 0.05 | 4.2 × E-2 | 3.3 × E-2 | 0.21 |

Season - winter | Reference | Reference | Reference | ||||||

- spring | -1.3 × E-2 | 8.9 × E-3 | 0.15 | -1.5 × E-2 | 7.7 × E-3 | 0.05 | -1.6 × E-2 | 1.1 × E-2 | 0.13 |

- summer | -2.9 × E-2 | 8.9 × E-3 | 0.001 | -2.4 × E-2 | 7.7 × E-3 | 0.002 | -2.3 × E-2 | 1.1 × E-2 | 0.03 |

- autumn | -1.4 × E-2 | 8.9 × E-3 | 0.11 | -1.5 × E-2 | 8.1 × E-3 | 0.07 | -1.2 × E-2 | 1.1 × E-2 | 0.27 |