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Table 4 Associations among nutrient intake and SNPs on LDL-C concentration according to three dietary assessment methods

From: Relationship between ethanol consumption and TBL2 rs17145738 on LDL-C concentration in Japanese adults: a four season 3-day weighed diet record study

 

Complete case dataseta

Observed subject datasetb

Multiple imputation dataset (m = 100)c

β

S.E.

P

β

S.E.

P

β

S.E.

P

Cross-sectional study

 FFQ (one year)d

  Number of observations (person · season)

 

51

  

73

  

78

 

  Cholesterol (mg/MJ)

4.5 × E-2

1.8 × E-1

0.81

2.4 × E-2

1.4 × E-1

0.87

3.3 × E-2

1.4 × E-1

0.81

  PSRC1 rs599839

9.7 × E-2

5.0 × E-1

0.85

2.3 × E-2

4.6 × E-1

0.96

3.7 × E-2

4.5 × E-1

0.94

  Interaction

-1.1 × E-1

3.4 × E-1

0.74

-7.0 × E-2

3.1 × E-1

0.82

-7.7 × E-2

3.1 × E-1

0.80

  Cholesterol (mg/MJ)

1.5 × E-2

2.0 × E-1

0.94

-3.1 × E-2

1.6 × E-1

0.85

-2.4 × E-2

1.5 × E-1

0.87

  TIMD4 rs6882076

-2.0 × E-1

4.6 × E-1

0.67

-8.1 × E-2

4.0 × E-1

0.84

-1.0 × E-1

4.0 × E-1

0.79

  Interaction

1.2 × E-1

3.0 × E-1

0.70

7.0 × E-2

2.6 × E-1

0.79

8.1 × E-2

2.6 × E-1

0.75

  TDF (g/MJ)

-1.7 × E-1

2.6 × E-1

0.53

-1.3 × E-1

2.3 × E-1

0.56

-8.4 × E-2

2.2 × E-1

0.70

  - rs651007

3.5 × E-2

5.3 × E-2

0.51

1.5 × E-2

4.6 × E-2

0.75

2.5 × E-2

4.4 × E-2

0.57

  Interaction

1.6 × E-1

2.9 × E-1

0.59

2.1 × E-1

2.6 × E-1

0.40

1.6 × E-1

2.5 × E-1

0.52

  TDF (g/MJ)

-2.0 × E-1

2.1 × E-1

0.35

-9.8 × E-2

1.7 × E-1

0.57

-9.8 × E-2

1.7 × E-1

0.57

  TOMM40 rs1160985

-1.1 × E-1

5.5 × E-2

0.05

-1.2 × E-1

4.4 × E-2

0.008

-1.2 × E-1

4.3 × E-2

0.007

  Interaction

2.8 × E-1

2.8 × E-1

0.32

3.0 × E-1

2.3 × E-1

0.20

3.0 × E-1

2.3 × E-1

0.18

  Ethanol (g/day)

-8.5 × E-2

2.9 × E-2

0.006

-3.7 × E-2

2.3 × E-2

0.11

-3.3 × E-2

2.3 × E-2

0.16

  TBL2 rs17145738

-9.3 × E-2

5.1 × E-2

0.07

-5.4 × E-2

4.4 × E-2

0.23

-4.7 × E-2

4.5 × E-2

0.30

  Interaction

3.1 × E-2

4.8 × E-2

0.52

-8.6 × E-3

4.3 × E-2

0.84

-1.3 × E-2

4.3 × E-2

0.77

 First season 3-day WDRsd

  Number of observations (person · season)

 

51

  

72

  

78

 

  Cholesterol (mg/MJ)

1.7 × E-2

1.3 × E-1

0.90

-6.7 × E-2

9.2 × E-2

0.47

-6.0 × E-2

8.8 × E-2

0.50

  PSRC1 rs599839

-1.1 × E+0

5.5 × E-1

0.04

-8.6 × E-1

3.8 × E-1

0.03

-8.4 × E-1

3.7 × E-1

0.03

  Interaction

6.8 × E-1

3.5 × E-1

0.06

5.0 × E-1

2.4 × E-1

0.04

4.9 × E-1

2.4 × E-1

0.05

  Cholesterol (mg/MJ)

1.3 × E-2

1.7 × E-1

0.94

-9.4 × E-3

1.1 × E-1

0.93

-5.4 × E-3

1.0 × E-1

0.96

  TIMD4 rs6882076

-2.3 × E-1

4.0 × E-1

0.57

2.5 × E-2

3.1 × E-1

0.94

6.0 × E-2

3.1 × E-1

0.85

  Interaction

1.4 × E-1

2.6 × E-1

0.60

-3.4 × E-3

2.0 × E-1

0.99

-2.7 × E-2

2.0 × E-1

0.89

  TDF (g/MJ)

-2.6 × E-1

1.4 × E-1

0.07

-1.9 × E-1

1.3 × E-1

0.14

-1.4 × E-1

1.3 × E-1

0.26

  - rs651007

6.8 × E-2

5.6 × E-2

0.23

1.1 × E-2

4.5 × E-2

0.82

2.3 × E-2

4.5 × E-2

0.61

  Interaction

-7.6 × E-2

2.0 × E-1

0.71

1.5 × E-1

1.7 × E-1

0.37

9.6 × E-2

1.7 × E-1

0.56

  TDF (g/MJ)

-2.7 × E-1

2.0 × E-1

0.19

-7.1 × E-2

1.3 × E-1

0.58

-6.9 × E-2

1.3 × E-1

0.58

  TOMM40 rs1160985

-3.9 × E-2

6.4 × E-2

0.55

-4.8 × E-2

4.7 × E-2

0.32

-6.1 × E-2

4.6 × E-2

0.19

  Interaction

-1.1 × E-2

2.2 × E-1

0.96

-3.3 × E-2

1.7 × E-1

0.84

-1.0 × E-2

1.6 × E-1

0.95

  Ethanol (g/day)

-7.7 × E-2

3.4 × E-2

0.03

-6.3 × E-2

2.5 × E-2

0.02

-5.1 × E-2

2.5 × E-2

0.05

  TBL2 rs17145738

-6.6 × E-2

5.5 × E-2

0.24

-6.8 × E-2

4.7 × E-2

0.15

-6.3 × E-2

4.6 × E-2

0.18

  Interaction

2.5 × E-2

7.0 × E-2

0.72

2.2 × E-2

6.4 × E-2

0.73

1.6 × E-2

6.3 × E-2

0.80

Seasonal variation research

 Four season 3-day WDRse

  Number of observations (person · season)

 

204

  

262

  

312

 

  Cholesterol (mg/MJ)

5.6 × E-2

3.2 × E-2

0.08

3.7 × E-2

2.7 × E-2

0.18

3.2 × E-2

4.3 × E-2

0.46

  PSRC1 rs599839

-2.9 × E-1

1.5 × E-1

0.05

-2.9 × E-1

1.3 × E-1

0.02

-2.9 × E-1

1.6 × E-1

0.07

  Interaction

1.5 × E-1

8.9 × E-2

0.10

1.5 × E-1

7.7 × E-2

0.05

1.5 × E-1

1.0 × E-1

0.12

Season - Winter

Reference

Reference

Reference

   - Spring

-1.8 × E-2

9.0 × E-3

0.05

-1.9 × E-2

7.7 × E-3

0.01

-2.0 × E-2

1.1 × E-2

0.06

   - Summer

-2.9 × E-2

9.0 × E-3

0.001

-2.6 × E-2

7.7 × E-3

<0.001

-2.5 × E-2

1.1 × E-2

0.02

   - Autumn

-1.9 × E-2

9.0 × E-3

0.04

-1.8 × E-2

8.2 × E-3

0.03

-1.5 × E-2

1.1 × E-2

0.18

  Cholesterol (mg/MJ)

3.8 × E-2

3.6 × E-2

0.29

2.9 × E-2

3.0 × E-2

0.34

2.4 × E-2

4.7 × E-2

0.60

  TIMD4 rs6882076

-1.8 × E-1

1.1 × E-1

0.09

-1.3 × E-1

9.4 × E-2

0.18

-9.9 × E-2

1.2 × E-1

0.42

  Interaction

1.2 × E-1

6.6 × E-2

0.07

9.2 × E-2

5.8 × E-2

0.12

7.5 × E-2

7.7 × E-2

0.33

Season - winter

Reference

Reference

Reference

   - spring

-1.7 × E-2

9.0 × E-3

0.07

-1.8 × E-2

7.7 × E-3

0.02

-1.9 × E-2

1.0 × E-2

0.08

   - summer

-3.1 × E-2

9.0 × E-3

<0.001

-2.7 × E-2

7.7 × E-3

<0.001

-2.5 × E-2

1.1 × E-2

0.02

   - autumn

-1.9 × E-2

9.0 × E-3

0.04

-1.8 × E-2

8.2 × E-3

0.03

-1.5 × E-2

1.1 × E-2

0.19

  TDF (g/MJ)

3.1 × E-2

4.2 × E-2

0.46

1.8 × E-2

3.9 × E-2

0.64

7.0 × E-3

5.4 × E-2

0.90

  - rs651007

7.3 × E-2

3.1 × E-2

0.02

6.8 × E-2

2.5 × E-2

0.007

6.3 × E-2

2.8 × E-2

0.03

  Interaction

-9.4 × E-2

6.5 × E-2

0.15

-8.9 × E-2

5.7 × E-2

0.12

-6.3 × E-2

7.5 × E-2

0.40

Season - winter

Reference

Reference

Reference

   - spring

-1.5 × E-2

9.1 × E-3

0.10

-1.7 × E-2

7.8 × E-3

0.03

-1.8 × E-2

1.1 × E-2

0.09

   - summer

-2.9 × E-2

9.2 × E-3

0.002

-2.6 × E-2

7.9 × E-3

<0.001

-2.4 × E-2

1.1 × E-2

0.03

   - autumn

-1.5 × E-2

9.0 × E-3

0.11

-1.5 × E-2

8.2 × E-3

0.07

-1.2 × E-2

1.1 × E-2

0.27

  TDF (g/MJ)

-4.7 × E-2

6.6 × E-2

0.47

-7.5 × E-2

5.4 × E-2

0.17

-5.5 × E-2

8.0 × E-2

0.49

  TOMM40 rs1160985

-6.0 × E-2

3.3 × E-2

0.07

-7.5 × E-2

2.6 × E-2

0.005

-7.0 × E-2

3.1 × E-2

0.03

  Interaction

5.8 × E-2

7.5 × E-2

0.44

8.1 × E-2

6.3 × E-2

0.20

5.8 × E-2

8.7 × E-2

0.50

Season - winter

Reference

Reference

Reference

   - spring

-1.6 × E-2

9.4 × E-3

0.10

-1.8 × E-2

7.9 × E-3

0.03

-1.8 × E-2

1.1 × E-2

0.09

   - summer

-2.9 × E-2

9.4 × E-3

0.002

-2.6 × E-2

7.9 × E-3

0.001

-2.4 × E-2

1.1 × E-2

0.03

   - autumn

-1.5 × E-2

9.2 × E-3

0.10

-1.6 × E-2

8.3 × E-3

0.06

-1.3 × E-2

1.1 × E-2

0.24

  Ethanol (g/day)

-3.0 × E-2

1.5 × E-2

0.05

-2.9 × E-2

1.2 × E-2

0.01

-3.6 × E-2

1.7 × E-2

0.03

  TBL2 rs17145738

-7.0 × E-2

3.7 × E-2

0.06

-7.3 × E-2

2.9 × E-2

0.02

-6.9 × E-2

3.3 × E-2

0.04

  Interaction

4.3 × E-2

3.0 × E-2

0.15

4.7 × E-2

2.4 × E-2

0.05

4.2 × E-2

3.3 × E-2

0.21

Season - winter

Reference

Reference

Reference

   - spring

-1.3 × E-2

8.9 × E-3

0.15

-1.5 × E-2

7.7 × E-3

0.05

-1.6 × E-2

1.1 × E-2

0.13

   - summer

-2.9 × E-2

8.9 × E-3

0.001

-2.4 × E-2

7.7 × E-3

0.002

-2.3 × E-2

1.1 × E-2

0.03

   - autumn

-1.4 × E-2

8.9 × E-3

0.11

-1.5 × E-2

8.1 × E-3

0.07

-1.2 × E-2

1.1 × E-2

0.27

  1. Abbreviations: SNP single nucleotide polymorphism, LDL-C LDL cholesterol, FFQ food frequency questionnaire, TDF total dietary fiber, 3-day WDRs 3-day weighed dietary records, m number of imputations. The following variables were log-transformed to improve the normality: LDL-C concentration; dietary cholesterol; TDF; ethanol consumption; BMI; physical activity. P <0.05 was shown as bold. aComplete case dataset was composed of subjects without missing values on four seasons. bObserved subjects dataset included all subjects from whom data were collected in each season for analysis, even if there were some missing values. cMultiple imputation datasets were calculated by means of applying the MI procedure to the observed subjects dataset. dMultiple regression models were applied for the analysis of the association among nutrient intake and SNPs on LDL-C concentration with adjustments for age, sex (0, men; 1, women), BMI, physical activity, ethanol consumption, smoking status (0, non-smoker; 1, smoker) and energy intake. eMixed-effect models were applied for the analysis of the association among nutrient intake and SNPs on LDL-C concentration with fixed effect: season (1, winter; 2, spring; 3 summer; 4, autumn), age, sex (0, men; 1, women), BMI, physical activity, ethanol consumption, smoking status (0, non-smoker; 1, smoker) and energy intake and random intercept: subject ID.
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