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Table 2 Changes in the hematological and biochemical parametersa

From: Efficacy of transdermal delivery of liposomal micronutrients through body oil massage on neurodevelopmental and micronutrient deficiency status in infants: results of a randomized placebo-controlled clinical trial

  LMF oil Placebo oil Treatment effect (95% CI)
  N Value Adjusted mean changeb N Value Adjusted mean changeb
Changes in hemoglobin (Hb) levels, gm%
Hb at 6 months 199 10.84 ± 0.88 −0.50 204 10.96 ± 0.90 − 0.54 − 0.01(− 0.26–0.28)
Hb at 12 months 190 10.36 ± 1.26 201 10.42 ± 1.30
Subgroup of children with no anemia (Hb > 11 g%) at 6 monthse
Hb at 6 months 88 11.61 ± 0.41 −0.70 101 11.68 ± 0.55 − 0.62 −0.08(− 0.38–0.23)
Hb at 12 months 84 10.90 ± 1.03 99 11.05 ± 1.09
Subgroup of children with mild anemia (Hb 10–11 g%) at 6 monthse
Hb at 6 months 85 10.51 ± 0.28 −0.44 77 10.52 ± 0.32 − 0.41 −0.03(− 0.37–0.31)
Hb at 12 months 84 10.08 ± 1.23 76 10.08 ± 1.10
Subgroup of children with moderate anemia(Hb 7- < 10 g%) at 6 monthse
Hb at 6 months 26 9.31 ± 0.56 0.11 26 9.49 ± 0.33 − 0.51 0.62(0.02–1.22)c
Hb at 12 months 22 9.34 ± 1.26 26 8.98 ± 1.04
Changes in transferrin saturation (TSAT) levels, %
TSAT at 6 months 199 12.1(7.89–15.9) −2.36 204 10.9(7.9–15.45) −2.10 −0.26(−1.89–1.36)
TSAT at 12 months 189 7.9(5.9–13.3) 201 8.1(5.8–11.7)
Change in 25-Hydroxy vitamin D (25-OH-D) levels, ng/ml
25 OH D at 6 months 199 20.4(13.7–29) 1.46 204 20.85(12–30.05) −0.18 1.63(− 0.52–3.78)d
25OH D at 12 months 189 23.7(17.6–30.4) 201 21.80(16.9–27.9)
  1. aValues expressed as Mean+/−SD for parametric data and median (interquartile range) for nonparametric data; bParameters adjusted for compliance to the intervention, concomitant administration of iron and vitamin D supplements; cp = 0.043, d = 0.049; e-Subgroup analysis additionally adjusted for gender, weaning age and maternal education, LMF oil Liposomal encapsulated micronutrient fortified oil