Efficacy of transdermal delivery of liposomal micronutrients through body oil massage on neurodevelopmental and micronutrient deficiency status in infants: results of a randomized placebo-controlled clinical trial

Table 3 Odds ratios for more than median (50^th centile) developmental score

Parameter	N	OR for placebo oil	OR for LMF oil	95% CI
Motor DQ^a	391	1	1.09	0.73–1.64
Mental DQ^a	391	1	0.97	0.65–1.44
Subgroup analysis for motor DQ^b
Hemoglobin at 6 months
No anemia	182	1	1.04	0.56–1.95
Mild anemia	155	1	1.72	0.85–3.50
Moderate anemia	48	1	0.64	0.15–2.80
Transferrin saturation at 6 months
TSAT < 16%	299	1	1.09	0.68–1.76
TSAT > 16%	88	1	1.10	0.43–2.83
Vitamin D levels at 6 months
Sufficient (≥20 ng/ml)	202	1	0.83	0.46–1.49
Insufficient (12–20 ng/ml)	102	1	3.38	1.30–8.82*
Inadequate (< 12 ng/ml)	83	1	0.66	0.24–1.82
Analysis for individual clusters of DASII^a
Social interaction	390	1	1.51	1.00–2.29 **
Locomotion: Coordinated movements	390	1	1.02	0.66–1.58
Language and vocabulary	390	1	1.25	0.81–1.94
Body control	390	1	1.55	0.73–3.28

* p = 0.013, ** p = 0.047;^a Multiple logistic regression adjusted for concomitant medicines and compliance; ^b For subgroups, analysis additionally adjusted for gender, weaning age, and maternal education; LMF oil Liposomal encapsulated micronutrient fortified oil, DQ Developmental quotient, DASII Developmental assessment of Indian infants, TSAT Transferrin saturation, OR Odd’s ratio

ISSN: 2055-0928