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Table 3 Effect of lipid-based nutrient supplements on change in the glucose and insulin markers among 268 HIV patients after 3 months of antiretroviral therapy initiation

From: Effects of nutritional supplementation on glucose metabolism and insulin function among people with HIV initiating ART

 

Non-supplemented (reference, n = 89)

Supplemented (n = 179)

Difference

 
 

Adjusted means (95% CI)

Adjusted means (95% CI)

B (95% CI)

P value

Glycated hemoglobin, mmol/mol

34.0 (32.2; 35.7)

35.9 (34.8; 37.1)

2.0 (−0.1; 4.1)

0.067

Plasma-glucose, mmol/l

 Fasting

5.7 (5.5; 5.8)

5.8 (5.7; 5.9)

0.1 (−0.04; 0.3)

0.145

 30 min

7.4 (7.2; 7.7)

7.9 (7.7; 8.1)

0.5 (0.2; 0.8)

0.003

 2 h

6.3 (6.0; 6.6)

6.7 (6.5; 6.9)

0.4 (0.03; 0.8)

0.035

 

Adjusted geometric means (95% CI)

Adjusted geometric means (95% CI)

10B (95% CI)

P value

Fasting plasma-insulin, μIU/mla

3.3 (2.7; 4.1)

5.2 (4.4; 6.4)

1.57 (1.20;2.05)

0.001

HOMA-Ba

31.2 (25.0; 39.0)

48.2 (41.1; 56.4)

1.54 (1.17; 2.03)

0.002

HOMA-IRa

0.80 (0.64; 1.00)

1.31 (1.12; 1.54)

1.64 (1.25;2.15)

< 0.001

  1. Beta estimates are presented after a linear regression with 95% confidence interval adjusted for age, sex, educational status and baseline status of outcome variables
  2. Data available: HbA1c: 227 at baseline and 192 at 3 months. Fasting: 264 at baseline and 249 at 3 months. 30 m-PG: 264 at baseline and 248 at 3 months. 2 h-PG: 265 at baseline and 247 at 3 months. Plasma fasting insulin: 265 at baseline and 246 at 3 months
  3. HOMA-B: 262 at baseline and 246 at 3 months. HOMA-IR: 263 at baseline and 246 at 3 months
  4. Abbreviations: CI Confidence interval, HIV Human immunodeficiency virus, HOMA-B Homeostatic model assessment of beat cell function and HOMA-IR Insulin resistance
  5. aAdjusted means and differences are based on log10-transformed variables. Hence, the means presented are therefore geometric means and the differences should be interpreted as ratios