Table 4 Magnitude of change in Hct status of the children

SCSB

0.646 ± 0.1

4.126 ± 0.31

19.067 (0.2)

0.001*

CSB

0.691 ± 0.1

1.241 ± 0.14

8.12 (0.4)

0.410

Placebo

0.650 ± 0.1

0.181 ± 0.33

-12.9 (0.4)

0.656

Baseline

End line

DID (95% CI)

P-value

difference

Difference

Mean of SCSB minus mean of CSB

−0.005

2.885

3.775

0.001*

Mean of SCSB minus mean of Placebo

−0.004

3.945

4.835

0.0001*

Mean of CSB minus mean of placebo

0.001

1.06

0.106

0.088

RR(95%CI)

Z statistics

P-value

SCSB n = 4 Vs CSB n = 55

3.15 (1.91–2.07)

8.12

0.002*

SCSB n = 4 Vs placebo n = 64

4.07 (3.63–3.76)

12.45

0.0001*

CSB n = 55 Vs placebo n = 64

1.77 (1.68–1.76)

4.61

0.182

Placebo n = 64 (86.5%)

1

X²-Log-rank (95%CI)

P-value

SCSB Vs CSB

0.978 (0.954–1.033)

0.001*

SCSB Vs placebo

0.971 (0.943–0.984)

0.0001*

CSB Vs Placebo

1.901 (0.881–0.933)

0.701

Placebo

1

Mean recovery time in days (CI)

P-value

SCSBVs CSB

8 (7–12)

0.002*

SCSB Vs placebo

19 (20–23)

0.001*

CSB Vs Placebo

33 (31–35)

0.002*

Placebo

1