Table 1 Characteristics of studies reporting on the mean platelet volume in individuals with obesity (n = 13)

Arslan [15]

2010

Turkey

47 Non-obese

56 Obese

(BMI ≥ 27 kg/m²)

To investigate the

MPV levels in obese adolescents. Moreover, to compare the

MPV levels between patients with or without NAFLD

and healthy controls

Obese adolescents had significantly higher MPV levels compared to healthy controls. In addition, the MPV is inversely associated with HDL cholesterol levels and platelet counts

EDTA,

Sysmex XE-500

Reference range:

7.2–11.1 fL

Coban [17]

2005

Turkey

100 Non-obese

(BMI < 26.6)

100 Obese

(BMI ≥ 30 kg/m²)

To evaluate MPV in patients with obesity compared to non-obese controls

The MPV is increased in individuals with obesity when compared to the control group. In addition, the MPV was positively associated with BMI

Citrate,

Abbot Cell-Dyn 3500

Coban [18]

2007

Turkey

30 Non-obese

(BMI < 27.7)

30 Obese women

(BMI ≥ 30 kg/m²)

To evaluate the effect of weight loss on the levels on the levels of MPV in obese patients

The MPV was higher in obese patients. Moreover, the MPV was directly associated with BMI

Citrate

Abbot Cell Dyn 3500

Erdal [19]

2019

Turkey

45 Non-obese

 < 21 kg/m²)

45 Obese

(BMI > 45 kg/m²)

To compare the complete blood counts, which included PCT and PLR values of healthy subjects with those of morbidly obese individuals in the young population

Platelet counts were increased in individuals with obesity. However, the MPV was comparable between lean and obese

NR

Esen [20]

2015

Turkey

204 Non-obese

(BMI < 27.2)

290 Obese

(BMI ≥ 30 kg/m²)

To compare the complete blood counts, which included PCT and PLR values of healthy subjects with those of morbidly obese individuals in the young population

The MPV was comparable between obese and non-obese individuals. Although the MPV was inversely correlated with BMI

EDTA,

Sysmex XE-500

(Sysmex Corp, Kobe, Japan)

Reference range:

7.2–11.1 fL

Furman-Niedzieko [21]

2014

Poland

129 Non-obese

(BMI 21.3–25.7 kg/m²)

218 Obese

(BMI > 25.1 kg/m²)

To assess the correlation between the platelet markers, especially the MPV, and the incidence of abdominal obesity in patients with the metabolic syndrome

The MPV was higher in individuals with obesity compared to controls

NR;

SYSMEX XS-1000i

Furucouglu [24]

2016

Turkey

73 Non-obese

(BMI < 25.53 kg/m²)

74 Obese

(BMI ≥ 30–40 kg/m²)

To aim of our study was to evaluate the effect of weight and smoking status on CBC parameters and biomarkers

The MPV was comparable between obese and individuals with normal body weights. The BMI is positively correlated with platelet indices (Platelet distribution width, plateletcrit and platelet count) other than the MPV

NR

Hou [33]

2015

China

3527 Normal

(BMI < 24 kg/m²)

899 Obese

(BMI ≥ 28 kg/m²)

To investigate associations

between adiposity indices and platelet indices

The MPV was in lower in obese compared non-obese individuals. The MPV levels were strongly associated with white cell count

EDTA and Citrate;

CELL-DYN 3700, (Abbott, USA);

Reference range:

7–11 fL

Ozkan [22]

2015

Turkey

48 Non-obese

(BMI < 21 kg/m²)

60 Obese

(BMI ≥ 23.7 kg/m²)

To investigate the relation between MPV levels and CIMT measurements

The MPV was increased in obese children with non-alcoholic fatty liver disease

NR

Pinto [23]

2019

Brazil

33 Non-obese

(< 25 kg/m²)

69 Obese

(> 30 kg/m²)

To verify the influence of EDTA on MPV among normal overweight and obese patients

The MPV was increased in individuals with obesity compared to controls. The BMI and waist circumference were positively associated with the MPV

K3-EDTA

Cell-DYN Ruby analyser

Rihayi [32]

2018

Malaysia

56 Non-obese

(BMI 18.5–22.9 kg/m²)

28 Obese

(BMI 25.5-35 kg/m²)

To evaluate associations between markers of platelet activation and inflammation in men and women with varying body mass indices

The MPV was elevated in individuals with obesity when compared to controls. Moreover, the MPV was directly associated with the white cell count

EDTA;

Sysmex KX-21

Tavil [34]

2006

Turkey

140 Non-obese

205 Obese

(Abdominal obesity: > 102 cm in men; and > 88 cm in women)

to determine whether MPV values are increased in patients with MS, and secondly to evaluate the relationship between the severity of atherosclerosis and MPV patients with MS

The MPV was significantly increased in individuals with obesity

K3-EDTA

Cell-DYN 3500

(Abbot, IL, USA)

Reference range:

7.0–11.00 fL

Yilmaz[9]

2015

Turkey

16 Non-obese

(BMI < 25 kg/m²)

25 Obese

(BMI ≥ 25 kg/m

To compare hsCRP, MPV and NLR levels in lean and obese PCOS patients

The MPV is increased in individuals with obesity when compared to the control group. In addition, the MPV was positively associated with the BMI

Sysmex XE-2100