Parameters | Placebo (n = 31) | Mean change | DRB (n = 30) | Mean change | ||||
---|---|---|---|---|---|---|---|---|
Baseline | Week 6 | Week 12 | Baseline | Week 6 | Week 12 | |||
Anthropometric parameters | ||||||||
  Body weight (kg) | 75.38 ± 15.56 | 75.3 ± 15.63 | 75.28 ± 15.29 |  − 0.10 ± 1.80 | 77.76 ± 16.75 | 78.00 ± 16.60 | 77.99 ± 16.51 | 0.20 ± 1.39 |
  BMI (kg/m2) | 28.10 ± 4.50 | 28.12 ± 4.56 | 28.13 ± 4.56 | 0.03 ± 0.71 | 29.45 ± 4.57 | 29.52 ± 4.64 | 29.55 ± 4.66 | 0.06 ± 0.63 |
  Waist circumference (cm) | 93.60 ± 11.03 | 93.31 ± 11.24 | 93.44 ± 11.27 |  − 0.16 ± 1.19 | 95.09 ± 10.86 | 95.40 ± 11.06 | 95.28 ± 10.81 | 0.15 ± 0.93 |
  Fat mass (kg) | 27.68 ± 10.26 | 27.59 ± 10.54 | 27.43 ± 10.03 |  − 0.25 ± 1.68 | 30.21 ± 10.20 | 30.26 ± 10.52 | 30.46 ± 10.26 | 0.23 ± 1.33 |
  Fat-free mass (kg) | 47.74 ± 10.82 | 47.82 ± 10.70 | 47.69 ± 10.99 |  − 0.05 ± 1.16 | 47.48 ± 10.43 | 47.48 ± 10.25 | 47.60 ± 10.41 | 0.10 ± 1.09 |
  Muscle mass (kg) | 45.02 ± 10.38 | 45.10 ± 10.25 | 45.03 ± 10.62 | 0.02 ± 1.09 | 44.52 ± 10.48 | 44.90 ± 9.94 | 44.93 ± 10.02 | 0.37 ± 2.26 |
  Relative fat mass | 37.60 ± 6.63 | 37.47 ± 6.66 | 37.52 ± 6.62 |  − 0.08 ± 0.49 | 38.30 ± 5.58 | 38.39 ± 5.69 | 38.37 ± 5.68 | 0.05 ± 0.31 |
  Visceral adiposity index | 2.07 ± 1.00 | 2.07 ± 0.96 | 2.01 ± 0.99 |  − 0.04 ± 0.69 | 1.64 ± 0.96 | 1.50 ± 0.67 | 1.54 ± 0.93 |  − 0.13 ± 0.77 |
  SBP (mmHg) | 122.13 ± 15.05 | 121.32 ± 14.60 | 123.52 ± 13.93 | 1.39 ± 9.67 | 126.20 ± 13.63a | 123.33 ± 13.07a,b | 120.60 ± 13.72b |  − 5.6 ± 8.37 |
  DBP (mmHg) | 78.45 ± 10.32 | 80.00 ± 8.19 | 79.19 ± 8.81 | 0.74 ± 7.13 | 80.87 ± 7.38a | 77.40 ± 10.89b | 77.17 ± 9.83c |  − 3.7 ± 7.50 |
Blood biochemical parameters | ||||||||
  FBG (mg/dL) | 99.13 ± 27.95 | 100.35 ± 30.88 | 101.19 ± 31.79 | 2.06 ± 9.27 | 94.93 ± 22.79 | 96.60 ± 21.98 | 96.57 ± 22.40 | 1.63 ± 6.88 |
  HbA1c (%) | 5.89 ± 0.67a | 5.81 ± 0.79a,b | 5.78 ± 0.69b |  − 0.11 ± 0.18 | 5.89 ± 0.76a | 5.77 ± 0.70b | 5.66 ± 0.62c |  − 0.23 ± 0.28 |
  Insulin (uIU/mL) | 9.16 ± 4.28 | 8.86 ± 4.59 | 8.99 ± 5.04 |  − 0.35 ± 2.87 | 8.50 ± 4.37 | 8.25 ± 3.26 | 8.38 ± 3.88 |  − 0.13 ± 2.40 |
  HOMA-IR | 2.10 ± 1.04 | 2.06 ± 1.08 | 2.10 ± 1.29 | 0.07 ± 0.77 | 2.14 ± 1.50 | 2.13 ± 1.46 | 2.15 ± 1.53 | 0.01 ± 0.58 |
  QUICKI | 0.35 ± 0.03 | 0.35 ± 0.04 | 0.35 ± 0.04 | 0.00 ± 0.02 | 0.35 ± 0.03 | 0.35 ± 0.04 | 0.35 ± 0.03 |  − 0.00 ± 0.02 |
  TC (mg/dL) | 236.32 ± 30.44 | 230.94 ± 34.40 | 238.03 ± 36.59 | 1.71 ± 20.03 | 246.40 ± 45.22 | 242.00 ± 46.45 | 238.27 ± 47.31 |  − 8.13 ± 22.43 |
  TG (mg/dL) | 131.27 ± 58.99 | 133.4 ± 59.42 | 130.10 ± 53.52 | 2.00 ± 43.71 | 121.52 ± 64.94 | 112 ± 46.87 | 112.24 ± 54.46 |  − 11.07 ± 56.02 |
  LDL (mg/dL) | 158.94 ± 33.57a | 164.58 ± 36.83a,b | 169.58 ± 35.11b | 10.65 ± 22.55 | 168.73 ± 37.59 | 165.40 ± 37.69 | 166.27 ± 41.54 |  − 2.47 ± 16.95 |
  HDL (mg/dL) | 51.35 ± 10.21 | 52.35 ± 11.10 | 53.23 ± 11.69 | 1.87 ± 6.32 | 57.7 ± 13.21 | 56.97 ± 14.42 | 57.63 ± 14.73 |  − 0.07 ± 7.05 |
  LDL:HDL ratio | 3.19 ± 0.80 | 3.25 ± 0.84 | 3.32 ± 0.93 | 0.14 ± 0.38 | 3.06 ± 0.87 | 3.04 ± 0.87 | 3.02 ± 0.86 |  − 0.04 ± 0.43 |
  hs-CRP (mg/L) | 2.74 ± 1.91 | 3.11 ± 3.30 | 2.79 ± 2.35 |  − 0.55 ± 3.21 | 1.88 ± 1.59 | 2.28 ± 1.83 | 2.09 ± 1.94 | 0.22 ± 1.35 |
  Homocysteine (μmol/L) | 10.69 ± 3.07 | 10.37 ± 2.87 | 11.06 ± 2.46 | 0.36 ± 2.99 | 11.37 ± 3.29 | 11.10 ± 3.12 | 10.98 ± 3.20 |  − 0.39 ± 2.30 |
Dietary intake parameters | ||||||||
  Energy (kcal/day) | 1,689.29 ± 428.64 | 1,715.08 ± 460.73 | 1,777.30 ± 444.95 | 88.01 ± 949.19 | 1,770.40 ± 257.16a | 1,723.56 ± 374.34a,b | 1,646.16 ± 339.87b |  − 124.24 ± 381.77 |
  Carbohydrate (g/day) | 212.29 ± 57.58 | 230.65 ± 77.81 | 233.93 ± 178.47 | 21.64 ± 184.05 | 225.37 ± 45.77 | 226.04 ± 42.55 | 216.55 ± 51.27 |  − 8.83 ± 58.16 |
  Protein (g/day) | 74.09 ± 31.16 | 69.65 ± 19.11 | 72.00 ± 32.94 |  − 2.09 ± 23.98 | 71.94 ± 15.24 | 72.54 ± 17.62 | 71.45 ± 14.28 |  − 0.49 ± 21.40 |
  Fat (g/day) | 60.81 ± 20.72 | 56.72 ± 18.77 | 60.86 ± 26.05 | 0.05 ± 25.33 | 64.80 ± 16.39a | 58.84 ± 22.20a,b | 59.62 ± 21.88b |  − 9.77 ± 19.62 |
Energy distribution | ||||||||
  Carbohydrate (%) | 51.35 ± 7.03 | 53.12 ± 7.22 | 55.22 ± 28.18 | 3.87 ± 29.82 | 51.35 ± 7.53 | 51.63 ± 6.31 | 51.08 ± 5.47 |  − 0.27 ± 7.27 |
  Protein (%) | 17.10 ± 4.58 | 16.77 ± 3.06 | 17.99 ± 5.07 | 0.88 ± 4.90 | 16.37 ± 2.86 | 16.55 ± 2.47 | 17.34 ± 2.75 | 0.97 ± 3.70 |
  Fat (%) | 31.55 ± 6.04 | 30.11 ± 6.06 | 33.46 ± 8.33 | 1.92 ± 9.24 | 32.28 ± 6.37 | 31.82 ± 6.26 | 31.58 ± 6.06 |  − 0.70 ± 6.85 |
  Dietary fiber (g/day) | 6.98 ± 3.28 | 6.25 ± 2.88 | 7.47 ± 5.91 | 0.49 ± 5.57 | 9.48 ± 5.35a | 15.40 ± 2.99b | 15.38 ± 3.33c* | 5.90 ± 5.45 |