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Table 4 Fasting serum HDL-C based on SNPs and sexes in the examined genes

From: SNPs in apolipoproteins contribute to sex-dependent differences in blood lipids before and after a high-fat dietary challenge in healthy U.S. adults

Men

Women

Gene & genotype (n)

HDL-C (mg/dL)

Gene & genotype (n)

HDL-C (mg/dL)

APOA5

 

APOA5

 

 CC (0) + CG (25)

50.57 ± 2.72

CC (1) + CG (21)

52.88 ± 2.87

 GG (142)

49.00 ± 1.13

GG (160)

61.91 ± 1.06 a

 % change of the C allele

3.10%

% Change of the C allele

-17.08c

APOB

 

APOB

 

 GG (12) + AG (60)

49.16 ± 1.60

GG (15) + AG (67)

63.28 ± 1.50 a

 AA (93)

49.51 ± 1.40

AA (99)

58.60 ± 1.38 a

 % change of the G allele

-0.71

% Change of the G allele

7.40

APOC3

 

APOC3

 

 CC (28) + CT (80)

50.53 ± 1.31

CC (35) + CT (87)

61.10 ± 1.23 a

 TT (58)

46.94 ± 1.79

TT (59)

60.24 ± 1.78 a

 % change of the C allele

7.10

% Change of the C allele

1.41

APOE

 

APOE

 

 CC (2) + CT (38)

45.22 ± 2.16

CC (2) + CT (54)

59.45 ± 1.82 a

 TT (127)

50.50 ± 1.21

TT (126)

61.43 ± 1.21 a

 % change of the C allele

-11.68 b

% Change of the C allele

-3.33

LDLR

 

LDLR

 

 CT (29) + TT (2)

50.61 ± 2.45

CT (30) + TT (1)

64.46 ± 2.45 a

 CC (135)

48.89 ± 1.17

CC (151)

60.06 ± 1.11a

 % change of the T allele

3.40

% Change of the T allele

6.83

  1. Data were adjusted for age and BMI in each sex group and are presented as mean ± S.E
  2. a P < 0.01 between men and women of the indicated genotype
  3. b P < 0.05
  4. c P < 0.01 between genotypes of the indicated gene. The percent (%) change of HDL-C levels due to carrying the risk allele of each SNP was calculated by dividing the mean value of the difference between two genotypes of the SNP by the mean value of the risk allele and multiply the answer by 100