Table 5 Lipid concentrations after dietary challenge in subjects carrying both risk alleles of APOA5 and APOE
Gene & genotype (n) | Time (h) after dietary challenge | |||
|---|---|---|---|---|
0 | 0.5 | 3 | 6 | |
APOA5/APOE, GG/TT (224) a | ||||
 Triglycerides (mg/dL) | 87.05 ± 2.3 | 97.30 ± 2.6 | 178.5 ± 5.5 | 148.3 ± 4.7 |
 Total cholesterol (mg/dL) | 172.8 ± 2.11 | 180.8 ± 2.24 | 174.3 ± 2.16 | 176.9 ± 2.20 |
 HDL-C (mg/dL) | 56.07 ± 0.88 | 58.20 ± 0.91 | 53.35 ± 0.88 | 52.48 ± 0.88 |
 LDL-C (mg/dL) | 107.1 ± 1.90 | 111.2 ± 1.99 | 102.4 ± 1.84 | 104.8 ± 1.90 |
 NEFA (mEq/L) | 0.32 ± 0.01 | 0.23 ± 0.01 | 0.26 ± 0.01 | 0.56 ± 0.01 |
APOA5/APOE, CC + CG/CC + CT (18) b | ||||
 Triglycerides (mg/dL) | 93.09 ± 9.0 | 101.8 ± 9.9 | 199.7 ± 22.8 | 170.6 ± 19.9 |
 % change of the risk alleles | 6.49 | 4.42 | 10.62 | 13.07 |
 Total cholesterol (mg/dL) | 182.2 ± 7.85 | 191.7 ± 8.30 | 185.9 ± 8.00 | 189.1 ± 8.09 |
 % change of the risk alleles | 5.16 | 5.69 | 6.24 | 6.45 |
 HDL-C (mg/dL) | 49.99 ± 3.28 | 52.96 ± 3.35 | 47.90 ± 3.25 | 47.30 ± 3.23 |
 % change of the risk alleles | -12.16 | -9.89 | -11.38 | -10.95 |
 LDL-C (mg/dL) | 122.0 ± 7.07 | 127.0 ± 7.36 | 117.8 ± 6.83 | 119.3 ± 6.99 |
 % change of the risk alleles | 12.21 * | 12.44 * | 13.07 * | 12.15 * |
 NEFA (mEq/L) | 0.30 ± 0.03 | 0.21 ± 0.03 | 0.27 ± 0.03 | 0.52 ± 0.04 |
 % change of the risk alleles | -6.67 | -9.52 | 3.70 | -7.69 |