Table 6 Lipid concentrations after dietary challenge in subjects carrying both risk alleles of APOC3 and APOE
Gene & genotype (n) | Time (h) after dietary challenge | |||
|---|---|---|---|---|
0 | 0.5 | 3 | 6 | |
APOC3/APOE, TT/TT (130) a | ||||
 Triglycerides (mg/dL) | 87.14 ± 2.94 | 97.17 ± 3.45 | 176.2 ± 7.02 | 148.6 ± 6.53 |
 Total cholesterol (mg/dL) | 178.0 ± 2.98 | 186.0 ± 3.15 | 179.1 ± 3.09 | 181.6 ± 3.13 |
 HDL-C (mg/dL) | 55.78 ± 1.30 | 58.00 ± 1.36 | 52.90 ± 1.29 | 52.35 ± 1.30 |
 LDL-C (mg/dL) | 112.6 ± 2.80 | 116.7 ± 2.91 | 107.8 ± 2.73 | 109.6 ± 2.80 |
 NEFA (mEq/L) | 0.33 ± 0.01 | 0.24 ± 0.01 | 0.25 ± 0.01 | 0.56 ± 0.01 |
APOC3/APOE, CC + CT/CC + CT (21) b | ||||
 Triglycerides (mg/dL) | 86.48 ± 7.53 | 96.38 ± 9.08 | 172.3 ± 17.66 | 140.5 ± 15.72 |
 % change of the risk alleles | -0.76 | -0.82 | -2.26 | -5.77 |
 Total cholesterol (mg/dL) | 184.1 ± 7.70 | 193.7 ± 8.35 | 186.6 ± 7.93 | 189.3 ± 8.02 |
 % change of the risk alleles | 3.31 | 3.98 | 4.02 | 4.07 |
 HDL-C (mg/dL) | 55.00 ± 3.36 | 57.59 ± 3.61 | 53.36 ± 3.12 | 52.22 ± 3.33 |
 % change of the risk alleles | -1.42 | -0.71 | 0.86 | -0.25 |
 LDL-C (mg/dL) | 121.5 ± 7.23 | 127.1 ± 7.72 | 117.7 ± 7.01 | 119.7 ± 7.16 |
 % change of the risk alleles | 7.33 | 8.18 | 8.41 | 8.44 |
 NEFA (mEq/L) | 0.29 ± 0.03 | 0.23 ± 0.03 | 0.21 ± 0.02 | 0.45 ± 0.03 |
 % change of the risk alleles | -13.79 | -1.72 | -15.96 | -24.28 ** |