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Table 1 Changes in weight, TGF-β, MCP-1, NF-κB and glycemic markers concentrations in study groups

From: Vitamin D supplementation and cardiac tissue inflammation in obese rats

Groups

ND

ND + vitamin D

HFD

HFD + vitamin D

P-value

Weight

290 ± 30

256 ± 26.90

425 ± 3.71

381 ± 7.80

0.001

TGF-β (ng/mg protein)

1.1 ± 0.4

1.25 ± 0.4

1.11 ± 0.3

0.86 ± 0.34

0.03

MCP-1 (ng/mg protein)

0.62 ± 0.15

0.53 ± 0.08

0.7 ± 0.07

0.38 ± 0.03

0.002

0.03

NF-kB

0.01 ± 0.002

0.012 ± 0.002

0.012 ± 0.001

0.01 ± 0.001

0.04*

0.03

Glucose (mmol/l)

7.3 ± 1.5

7.08 ± 3.2

10.37 ± 0.7

8.16 ± 2

0.11

Insulin (mIU/l)

9.4 ± 0.3

9.16 ± 1.04

13.2 ± 3.71

8.68 ± 1.43

0.04*

0.01

HOMA-IR

0.63 ± 0.14

0.56 ± 0.16

1.25 ± 0.4

0.65 ± 0.22

0.006*

0.008

  1. Data are presented as means ± SD. Statistical differences between groups were assessed by one-way ANOVA followed by Tukey’s test for Post Hoc analysis; TGF-β transforming growth factor β; MCP-1 monocyte chemoattractant protein-1; NF-κB nuklear factor kappa B. Bold values represent statistically significant threshold
  2. P value indicated inter group differences. P-value < 0.05 was considered as statistically significant
  3. Significant differences between HFD + vitamin D and HFD
  4. * Significant differences between HFD and ND
  5. Significant difference between ND and ND + vitamin D group