Table 3 Comparison between the mean biomarker values at four different time periods of the day and the mean of the four 24-collections of urine performed during the preceding days. Time was missing for 3 spot samples. Data are the mean (SD)
(1) 0–7 h | (2) 7–14 h | (3) 14–20 h | (4) 20–24 h | ANOVA P-value | |
|---|---|---|---|---|---|
Normal water intake | |||||
Sample count | 49 | 116 | 111 | 72 | |
Osmolality (mosmol/kg) Spot | 529 (234) | 564 (283) | 557 (305) | 562 (293) | 0.90 |
Spot – 24 h | -14 (243) | + 67 (239) | + 46 (237) | + 45 (212) | 0.26 |
Creatinine (mmol/L) Spot | 9.7 (5.7) | 9.3 (6.7) | 8.2 (6.1) | 8.5 (5.7) | 0.36 |
Spot – 24 h | + 1.3 (5.7) | + 2.0 (5.5) | 0.0 (4.9) | + 0.6 (3.7) | 0.03 1 |
Increased water intake | |||||
Sample count | 62 | 130 | 131 | 88 | |
Osmolality (mosmol/kg) Spot | 519 (211) | 462 (234) | 419 (252) | 397 (232) | 0.01 2 |
Spot – 24 h | + 72 (214) | + 44 (221) | -12 (208) | -48 (198) | 0.02 3 |
Creatinine (mmol/L) Spot | 10.5 (6.3) | 7.8 (5.5) | 6.5 (5.6) | 5.9 (4.7) | 0.001 4 |
Spot – 24 h | + 3.9 (6.0) | + 1.6 (5.3) | -0.1 (4.4) | -0.7 (4.1) | 0.001 5 |