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Table 3 Multiple logistic regression analysis of the association between selected host genes and anaemia and malaria

From: Effect of iron fortification on anaemia and risk of malaria among Ghanaian pre-school children with haemoglobinopathies and different ABO blood groups

 

Anaemia

 

Malaria

 

Host characteristics

aOR (95% CI)a

P-value

aOR (95% CI)a

P-value

Experimental group

 No iron

1

 

1

 

 Iron

0.85 (0.63-1.15)

0.303

0.95 (0.71-1.26)

0.708

G6PD genotypes

 A-A-

1

 

1

 

 AA

0.87 (0.51-1.50)

0.622

0.56 (0.32-0.96)

0.035

 AB

0.85 (0.45-1.59)

0.605

0.68 (0.37-1.27)

0.230

 BB

0.76 (0.46-1.26)

0.291

0.49 (0.30-0.82)

0.006

Hb genotypes

 AA

1

 

1

 

 AC

1.04 (0.58-1.86)

0.885

0.61 (0.35-1.07)

0.083

 AS

1.37 (0.86-2.20)

0.185

1.58 (0.99-2.51)

0.054

 CC

1.27 (0.36-4.49)

0.714

0.71 (0.23-2.23)

0.561

 SC

1.07 (0.57-2.01)

0.831

1.02 (0.56-1.89)

0.940

 SS

-

 

-

-

ABO group

 A

1

 

1

 

 AB

2.24 (1.03-4.85)

0.041

0.79 (0.42-1.51)

0.482

 B

1.02 (0.68-1.54)

0.922

1.23 (0.82-1.85)

0.315

 O

1.02 (0.71-1.45)

0.932

0.99 (0.70-1.39)

0.929

  1. Data reported as 95% confidence interval (95% CI), percentage (%) of participants, glucose-6-phosphate dehydrogenase (G6PD). For G6PD genotype: deficient variant or mutant = A-A-, non-deficient variant = AA, wild type = BB, intermediate type = AB, Haemoglobin (Hb), For Hb genotype: sickling traits (HbAS & HbSC), sickle disorder (HbSS), haemoglobin C traits (HbAC), normal or wild-type haemoglobin (HbAA), variant haemoglobin (HbCC)
  2. aAdjusted for child’s age and sex