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Table 5 Effect of host genes on clinical malaria episodes

From: Effect of iron fortification on anaemia and risk of malaria among Ghanaian pre-school children with haemoglobinopathies and different ABO blood groups

Number of participants, mean episodes (ranges)

Haemoglobin genotype

Iron Gp

Noniron Gp

p-values

G6PD Genotype

Iron Gp

Noniron Gp

p-values

ABO phenotype

Iron Gp

Noniron Gp

p-values

AA

325,0.9(0–5)

302,0.9(0–4)

0.3

A-A-

45,1.6(0–5)

51,1.6(0–5)

0.637

A

122,0.9(0–4)

122,0.7(0–4)

 < 0.001

AC

29,0.8(0–5)

34,0.8(0–3)

0.005

AA

123,1.3(0–5)

113,1.1(0–5)

0.065

AB

28,0.9(0–5)

19,0.7(0–3)

0.1

AS

49,1.2(0–4)

57,0.7(0–4)

0.005

AB

78,1.4(0–6)

73,1.4(0–5)

0.795

B

86,0.9(0–5)

106,0.9(0–4)

0.2

CC

5,0.8(0–3)

10,0.4(0–2)

0.4

BB

183,1.2(0–6)

191,1.2(0–5)

0.564

O

175,0.8(0–5)

166,0.9(0–4)

0.001

SC

23,0.6(0–4)

22,1.1(0–4)

0.6

        

SS

1,1.0(1–1)

3,1.0(0–2)

0.09

        
  1. Data reported as the number of participants (n), mean malaria episodes (f), group (Gp), glucose-6-phosphate dehydrogenase (G6PD), ABO blood groups (ABO); For G6PD genotype: deficient variant or mutant = A-A-, non-deficient variant = AA, wild type = BB, intermediate type = AB; Haemoglobin (Hb), For Hb genotype: sickling traits (HbAS & HbSC), sickle disorder (HbSS), haemoglobin C traits (HbAC), normal or wild-type haemoglobin (HbAA), variant haemoglobin (HbCC) and p-values were a two-sample Wilcoxon rank-sum (Mann–Whitney)