Fig. 1

Lifespan is extended when worms are exposed to 1000 µg/mL to Bioact®180. (a) Survival curves of wild type (strain, N2) animals exposed to Bioact®180 supplemented NGM. The animals in control conditions (blue line; n = 276) have a similar curve to those exposed to the vehicle control (0.2% DMSO; red line; n = 192), 30 µg/mL Bioact®180 (green line; n = 178) and 100 µg/mL Bioact®180 (purple line; n = 203). Exposure to 1000 µg/mL Bioact®180 (orange line; n = 145) shifts the curve to the right, displaying an increase in health span as well as a slight increase in maximal lifespan. (b) The restricted mean lifespan is calculated from the survival curves [32, 33] and plotted here. Error bars represent the standard error of mean (s.e.m.) and statistical differences were compared to the control using the Fisher’s Exact test at 50% mortality, where */^#p < 0.05 and **/^##p < 0.001 and * compares data to the no compound control and # to the DMSO vehicle control. All data is further described in Table 1