Effects of vitamin B12 supplementation on oxidative stress markers and pro-inflammatory cytokines during pregnancy and postpartum among Bangladeshi mother–child pairs

Table 3 Plasma 8-hydroxy-2′-deoxyguanosine (8-OH-dG) and cytokine concentrations of the participants from placebo and B12 supplementation group

Variables	Placebo (n = 33)	B12-group (n = 30)	p-value
8-OHdG (ng/mL)
Baseline	6.13 ± 1.85	4.99 ± 2.61	0.056
3 months postpartum (mother)	5.75 ± 3.01	3.81 ± 1.48	0.002
3 month (Infant)	5.41 ± 2.59	3.57 ± 1.57	0.001
IFN-γ (pg/mL)
Baseline	4.12 ± 2.19	6.26 ± 4.32	0.017
^a3 months postpartum (mother)	4.10 ± 2.41	5.74 ± 3.99	0.602
3 month (Infant)	4.73 ± 2.86	9.43 ± 6.20	< 0.001
TNF-α (pg/mL)
Baseline	2.22 ± 1.03	3.18 ± 1.65	0.296
3 months postpartum (mother)	2.11 ± 1.01	3.44 ± 3.56	0.043
3 months (Infant)	2.58 ± 1.29	3.31 ± 2.05	0.086
IL-10 (pg/mL)
Baseline	2.74 ± 0.77	3.70 ± 1.74	0.004
^a3 months postpartum (mother)	2.98 ± 2.25	3.19 ± 1.25	0.413
3 months (Infant)	6.14 ± 2.93	7.63 ± 3.02	0.041
IL-6 (pg/mL)
Baseline	5.49 ± 3.29	5.71 ± 2.68	0.321
3 months postpartum (mother)	4.36 ± 2.31	5.90 ± 2.23	0.011
3 months (Infant)	9.24 ± 8.33	9.44 ± 9.29	0.333
IL-4 (pg/mL)
Baseline	2.01 ± 1.13	2.53 ± 1.48	0.118
3 months postpartum (mother)	2.09 ± 1.10	3.25 ± 4.08	0.118
3 months (Infant)	2.02 ± 1.11	2.48 ± 1.54	0.150
IL-2 (pg/mL)
Baseline	1.79 ± 0.83	2.31 ± 0.99	0.024
^a3 months postpartum (mother)	1.87 ± 0.73	2.56 ± 2.35	0.642
3 months (Infant)	1.98 ± 0.61	2.25 ± 0.81	0.150

Data are presented as mean ± standard deviation (SD). Multivariate regression model was used to estimate the p-value and model was adjusted by mother’s age, BMI, mode of delivery; and infants’ birth weight and sex
^aAdjusted by baseline outcomes those were differed significantly at baseline

ISSN: 2055-0928