Table 2 Basic information of the population
Articles | Intervention | N | Calcium (mmol/L) | 25(OH)D nmol/L | 1,25(OH)2D (pmol/L) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Amount | Mean changes | P-value(changes) | P-value | Amount | Mean changes | P-value(changes) | P-value | Amount | Mean changes | P-value(changes) | P-value | |||
Bislev 2018 [20] | Placebo | 41 | 3.5 (2.7 to 5.2) | 0.0 (− 8.6 to 8.6) | < 0.0001 | NA | 33 ± 9 | − 13 (− 18 to − 8) | < 0.00001 | NA | 53 ± 13 | − 17 (− 22 to − 11) | < 0.00001 | NA |
Vitamin D | 40 | 3.5 (2.7 to 5.2) | 32.3 (18.0 to 46.7) | 33 ± 9 | 199 (167 to 234) | NA | 53 ± 13 | 42 (29 to 55) | NA | |||||
Boxer 2014 [21] | Placebo | 33 | 9.2 ± 0.4 | NA | NA | NA | 17.8 ± 9 | − 0.2 ± 6.6 | 0.001 | NA | NA | NA | NA | NA |
Vitamin D | 31 | 9.3 ± 0.5 | NA | NA | NA | 19.1 ± 9.3 | 42.3 ± 16.4 | NA | NA | NA | NA | |||
Grubler 2016 [22] | Placebo | 95 | 2.37 ± 0.11 | NA | NA | NA | 20.4 ± 5.7 ng/mL | < 0.001 | NA | NA | NA | NA | NA | |
Vitamin D | 92 | 2.37 ± 0.1 | NA | NA | NA | 21.8 ± 5.4 ng/mL | NA | NA | NA | NA | ||||
Pilz 2015 [23] | Placebo | 100 | 2.37 ± 0.11 | − 0.01 (− 0.03 to 0.01) | 0.259 | NA | 20.4 ± 5.7 | 3.3 (1.8 to 4.7) | < 0.001 | 0.86 | NA | NA | NA | NA |
Vitamin D | 100 | 2.37 ± 0.10 | 0.00 (− 0.02 to 0.01) | NA | 22 ± 5.5 | 14.2 (12.5 to 15.8) | NA | NA | NA | NA | ||||
Schroten 2013 [24] | Placebo | 51 | 2.3 ± 0.1 | − 0.01 | 0.1 | 0.85 | 46 (39–63) | 44 (39–49) | < 0.001 | NA | 142(117–170) | 132 (121–143) | < 0.001 | 0.8 |
Vitamin D | 50 | 2.3 ± 0.1 | 0.02 | 48(38–61) | 80 (75–87) | NA | 133(107–168) | 194 (179–211) | NA | |||||
Zittermann 2018 [25] | Placebo | 82 | 2.38 ± 0.11 | NA | NA | 0.634 | 36.7 (32.8–40.6) | 9.6 (3.8 to 15.4) | < 0.001 | 0.667 | 90.1 ± 33.5 | − 8.1 (− 15.8 to − 0.6) | < 0.001 | 0.252 |
Vitamin D | 83 | 2.38 ± 0.11 | NA | NA | NA | 36.9 (32.8–40.9) | 65.8 (54.5 to 77.1) | NA | 83.9 ± 34.3 | 12.2 (3.2 to 21.3) | NA | |||
Articles | Intervention | N | PAC (ng/dl) | |||||||||||
Amount | Mean changes | P-value(changes) | P-value | |||||||||||
Bislev 2018 [20] | Placebo | 41 | 38 (27 to 56) | 2.6 (− 14 to 22.3) | NA | 0.93 | ||||||||
Vitamin D | 40 | 39 (27 to 56) | 3.6 (− 10.6 to 20.1) | |||||||||||
Boxer 2014 [21] | Placebo | 33 | NA | NA | NA | NA | ||||||||
Vitamin D | 31 | NA | NA | NA | NA | |||||||||
Grubler 2016 [22] | Placebo | 95 | 16.8 ± 10.5 | 3.24 | NA | 0.04 | ||||||||
Vitamin D | 92 | 16.8 ± 10.6 | 0.88 | NA | ||||||||||
Pilz 2015 [23] | Placebo | 100 | 14.5 (10.5–19.7 | 3.3 (1.5 to 5.0) | NA | 0.125 | ||||||||
Vitamin D | 100 | 15.1 (9.5–19.1) | 0.9 (− 1.0 to 2.8) | |||||||||||
Schroten 2013 [24] | Placebo | 51 | NA | NA | NA | NA | ||||||||
Vitamin D | 50 | NA | NA | |||||||||||
Zittermann 2018 [25] | Placebo | 82 | NA | NA | NA | NA | ||||||||
Vitamin D | 83 | NA | NA | NA | NA | |||||||||
Articles | PRC (mIU/L) (ng/L)(µUmL) (pg/ml) | PRA (ng/mL per h) | |||||||
|---|---|---|---|---|---|---|---|---|---|
Amount | Mean changes | P-value(changes) | P-value | Amount | Mean changes | P-value(changes) | P-value | P-value | |
Bislev 2018 [20] | 4 (2.6 to 6.4) (pg/ml) | − 1.8 (23.2 to 25.7)(pg/ml) | 0.55 | NA | NA | NA | NA | NA | NA |
4 (2.6 to 6.4) | 7.1 (− 7.6 to 24.2)(pg/ml) | NA | NA | NA | NA | NA | NA | ||
Boxer 2014 [21] | NA | NA | NA | NA | 6.7 ± 8.6 | 9.2 ± 8 | 0.2 | NA | NA |
NA | NA | NA | NA | 7.6 ± 13.4 | 6.3 ± 7.0 | NA | NA | NA | |
Grubler 2016 [22] | 16.1 (9.5–51.6) µUmL | 28.79 µUmL | NA | 0.41 | NA | NA | NA | NA | NA |
16.3 (10.2–38.7) µUmL | -1.54 µUmL | NA | NA | NA | NA | NA | NA | NA | |
Pilz 2015 [23] | 16.7 (9.3–53.7) (µU/mL) | 28.8 (− 23.0 to 80.6)(µU/mL) | 0.128 | NA | NA | NA | NA | NA | NA |
15.5 (9.6–35.8)(µU/mL) | − 1.5 (− 8.1 to 5.0)(µU/mL) | NA | NA | NA | NA | NA | NA | ||
Schroten 2013 [24] | 67(17–181) (ng/L) | 72 (47–111)(ng/L) | 0.02 | 0.76 | 4.5 (1.4–17.5) | 7.3 (4.5–11.8) | 0.002 | 0.46 | 0.45 |
57(21–193)(ng/L) | 55 (32–93)(ng/L) | 5.4(2.5–28.1) | 5.2 (2.9–9.5) | ||||||
Zittermann 2018 [25] | 297 (141–752) (mIU/L) | NA | NA | 0.954 | NA | NA | NA | NA | NA |
300 (79–1277) (mIU/L) | NA | NA | NA | NA | NA | NA | NA | NA | |
Articles | PTH (pmol/l) (pg/mL) | ||||||||
Amount | Mean changes | P-value(changes) | P-value | ||||||
Bislev 2018 [20] | 6.1 (5.1 to 6.9) | 5.5 (1.3 to 9.8) | < 0.00001 | NA | |||||
6.1 (5.1 to 6.9) | − 11.4 (− 15.6 to − 7.2) | NA | |||||||
Boxer 2014 [21] | 72.8 ± 40.2(pg/mL) | − 3.1 ± 38.1 | 0.01 | NA | |||||
62.3 ± 44.3 | − 23.1 ± 40.0 | NA | |||||||
Grubler 2016 [22] | NA | NA | NA | NA | |||||
NA | NA | NA | NA | ||||||
Pilz 2015 [23] | 51.3 (38.8–63.7) | 1.7 (− 1.2 to 4.7) | 0.003 | NA | |||||
49.0 (40.0–61.5) | − 4.0 (− 6.5 to − 1.6) | NA | |||||||
Schroten 2013 [24] | 7.0 (4.4–9.2) | 0.3(0.1–0.4) | 0.004 | 0.45 | |||||
7.8 (4.7–10) | − 1.7(− 2.1 to − 0.3 | ||||||||
Zittermann 2018 [25] | NA | NA | NA | NA | |||||
NA | NA | NA | NA | ||||||