Weekly cholecalciferol supplementation results in significant reductions in infection risk among the vitamin D deficient: results from the CIPRIS pilot RCT

Table 2 Treatment predicting infection hazard, infection duration and infection severity

		All infections	Infections seen in clinic	All URTIs	URTIs seen in clinic
		n = 98 (54 placebo; 44 treatment)	n = 63 (34 placebo; 29 treatment)	n = 68 (32 placebo; 36 treatment)	n = 55 (28 placebo; 27 treatment)
Infection hazard (HR (95% CI))	Placebo	1.00 [reference]	1.00 [reference]	1.00 [reference]	1.00 [reference]
	Treatment	0.83 (0.53, 1.31)	0.86 (0.50, 1.50)	1.11 (0.75, 1.65)	0.98 (0.59, 1.63)
	Treatment	P = 0.42	P = 0.60	P = 0.62	P = 0.94
Infection duration (coefficient (95% CI))	Placebo	3.05 (2.35, 3.76)	4.15 (2.77, 5.53)	4.87 (3.29, 6.45)	5.28 (3.38, 7.18)
	Treatment	+1.04 (-0.25, 2.32)	+1.64 (-0.83, 4.11)	+0.51 (-1.80, 2.81)	+0.83 (-2.05, 3.70)
	Treatment	P = 0.11	P = 0.19	P = 0.67	P = 0.57
Maximum infection symptom severity (coefficient (95% CI))	Placebo	2.19 (1.81, 2.57)	2.19 (1.69, 2.70)	2.41 (1.89, 2.93)	2.42 (1.85, 3.00)
	Treatment	+0.08 (-0.49, 0.65)	+0.19 (-0.58, 0.95)	+0.03 (-0.69, 0.76)	-0.05 (-0.85, 0.76)
	Treatment	P = 0.79	P = 0.63	P = 0.93	P = 0.91
Total infection severity (coefficient (95% CI))	Placebo	12.26 (7.90, 16.62)	20.34 (9.01, 31.67)	25.47 (11.51, 39.43)	29.34 (12.28, 46.40)
	Treatment	+2.20 (-5.09, 9.49)	+5.95 (-13.15, 25.05)	-3.89 (-21.83, 14.06)	-2.87 (-25.70, 19.96)
	Treatment	P = 0.55	P = 0.54	P = 0.67	P = 0.81
Average daily total infection symptom severity (coefficient (95% CI))	Placebo	4.00 (3.25, 4.75)	4.74 (3.52, 5.96)	5.28 (3.73, 6.82)	5.41 (3.81, 7.02)
	Treatment	-0.26 (-1.34, 0.82)	-0.22 (-1.97, 1.52)	-1.08 (-3.00, 0.85)	-0.91 (-2.98, 1.16)
	Treatment	P = 0.64	P = 0.80	P = 0.27	P = 0.39

Infection hazard results are presented as HR (95% CI). Results for infection duration and severity are reported as geometric mean infection severity (95% CI) and then coefficient relative to the placebo group (95% CI). Note: a greater infection severity score or greater infection duration means a more severe infection or longer duration, respectively.

ISSN: 2055-0928