# Table 2 Treatment predicting infection hazard, infection duration and infection severity

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All infections

Infections seen in clinic

All URTIs

URTIs seen in clinic

nâ€‰=â€‰98 (54 placebo; 44 treatment)

nâ€‰=â€‰63 (34 placebo; 29 treatment)

nâ€‰=â€‰68 (32 placebo; 36 treatment)

nâ€‰=â€‰55 (28 placebo; 27 treatment)

Infection hazard (HR (95% CI))

Placebo

1.00 [reference]

1.00 [reference]

1.00 [reference]

1.00 [reference]

Treatment

0.83 (0.53, 1.31)

0.86 (0.50, 1.50)

1.11 (0.75, 1.65)

0.98 (0.59, 1.63)

Pâ€‰=â€‰0.42

Pâ€‰=â€‰0.60

Pâ€‰=â€‰0.62

Pâ€‰=â€‰0.94

Infection duration (coefficient (95% CI))

Placebo

3.05 (2.35, 3.76)

4.15 (2.77, 5.53)

4.87 (3.29, 6.45)

5.28 (3.38, 7.18)

Treatment

+1.04 (-0.25, 2.32)

+1.64 (-0.83, 4.11)

+0.51 (-1.80, 2.81)

+0.83 (-2.05, 3.70)

Pâ€‰=â€‰0.11

Pâ€‰=â€‰0.19

Pâ€‰=â€‰0.67

Pâ€‰=â€‰0.57

Maximum infection symptom severity (coefficient (95% CI))

Placebo

2.19 (1.81, 2.57)

2.19 (1.69, 2.70)

2.41 (1.89, 2.93)

2.42 (1.85, 3.00)

Treatment

+0.08 (-0.49, 0.65)

+0.19 (-0.58, 0.95)

+0.03 (-0.69, 0.76)

-0.05 (-0.85, 0.76)

Pâ€‰=â€‰0.79

Pâ€‰=â€‰0.63

Pâ€‰=â€‰0.93

Pâ€‰=â€‰0.91

Total infection severity (coefficient (95% CI))

Placebo

12.26 (7.90, 16.62)

20.34 (9.01, 31.67)

25.47 (11.51, 39.43)

29.34 (12.28, 46.40)

Treatment

+2.20 (-5.09, 9.49)

+5.95 (-13.15, 25.05)

-3.89 (-21.83, 14.06)

-2.87 (-25.70, 19.96)

Pâ€‰=â€‰0.55

Pâ€‰=â€‰0.54

Pâ€‰=â€‰0.67

Pâ€‰=â€‰0.81

Average daily total infection symptom severity (coefficient (95% CI))

Placebo

4.00 (3.25, 4.75)

4.74 (3.52, 5.96)

5.28 (3.73, 6.82)

5.41 (3.81, 7.02)

Treatment

-0.26 (-1.34, 0.82)

-0.22 (-1.97, 1.52)

-1.08 (-3.00, 0.85)

-0.91 (-2.98, 1.16)

Pâ€‰=â€‰0.64

Pâ€‰=â€‰0.80

Pâ€‰=â€‰0.27

Pâ€‰=â€‰0.39

1. Infection hazard results are presented as HR (95% CI). Results for infection duration and severity are reported as geometric mean infection severity (95% CI) and then coefficient relative to the placebo group (95% CI). Note: a greater infection severity score or greater infection duration means a more severe infection or longer duration, respectively.