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Table 2 Treatment predicting infection hazard, infection duration and infection severity

From: Weekly cholecalciferol supplementation results in significant reductions in infection risk among the vitamin D deficient: results from the CIPRIS pilot RCT

   All infections Infections seen in clinic All URTIs URTIs seen in clinic
n = 98 (54 placebo; 44 treatment) n = 63 (34 placebo; 29 treatment) n = 68 (32 placebo; 36 treatment) n = 55 (28 placebo; 27 treatment)
Infection hazard (HR (95% CI)) Placebo 1.00 [reference] 1.00 [reference] 1.00 [reference] 1.00 [reference]
Treatment 0.83 (0.53, 1.31) 0.86 (0.50, 1.50) 1.11 (0.75, 1.65) 0.98 (0.59, 1.63)
P = 0.42 P = 0.60 P = 0.62 P = 0.94
Infection duration (coefficient (95% CI)) Placebo 3.05 (2.35, 3.76) 4.15 (2.77, 5.53) 4.87 (3.29, 6.45) 5.28 (3.38, 7.18)
Treatment +1.04 (-0.25, 2.32) +1.64 (-0.83, 4.11) +0.51 (-1.80, 2.81) +0.83 (-2.05, 3.70)
P = 0.11 P = 0.19 P = 0.67 P = 0.57
Maximum infection symptom severity (coefficient (95% CI)) Placebo 2.19 (1.81, 2.57) 2.19 (1.69, 2.70) 2.41 (1.89, 2.93) 2.42 (1.85, 3.00)
Treatment +0.08 (-0.49, 0.65) +0.19 (-0.58, 0.95) +0.03 (-0.69, 0.76) -0.05 (-0.85, 0.76)
P = 0.79 P = 0.63 P = 0.93 P = 0.91
Total infection severity (coefficient (95% CI)) Placebo 12.26 (7.90, 16.62) 20.34 (9.01, 31.67) 25.47 (11.51, 39.43) 29.34 (12.28, 46.40)
Treatment +2.20 (-5.09, 9.49) +5.95 (-13.15, 25.05) -3.89 (-21.83, 14.06) -2.87 (-25.70, 19.96)
P = 0.55 P = 0.54 P = 0.67 P = 0.81
Average daily total infection symptom severity (coefficient (95% CI)) Placebo 4.00 (3.25, 4.75) 4.74 (3.52, 5.96) 5.28 (3.73, 6.82) 5.41 (3.81, 7.02)
Treatment -0.26 (-1.34, 0.82) -0.22 (-1.97, 1.52) -1.08 (-3.00, 0.85) -0.91 (-2.98, 1.16)
P = 0.64 P = 0.80 P = 0.27 P = 0.39
  1. Infection hazard results are presented as HR (95% CI). Results for infection duration and severity are reported as geometric mean infection severity (95% CI) and then coefficient relative to the placebo group (95% CI). Note: a greater infection severity score or greater infection duration means a more severe infection or longer duration, respectively.