Table 1 Exclusion criteria

• Person considered by the investigator to be unwilling, unlikely or unable to comprehend or comply with the study protocol

• Age <65 years

• Previous/current traumatic head/brain injury, neurological or psychiatric conditions

• Previous stroke

• Unstable use of anti–depressant medication (<6 months)

• Use of medication to treat anxiety

• Current or recent (in the last 6 months) malignancy

• Major liver, kidney, respiratory or gastrointestinal disease

• Current cardiovascular disease or angina

• Uncontrolled hypertension (>170/100)

• Current smoker

• Vegetarian (does not eat red meat, poultry or fish)

• Actively undertaking weight loss program

• Use of appetite suppressants or Orlistat (Xenical)

• Age and education adjusted scores of <13 on the DemTect

• Body mass >135 kg (limit on dual xray energy absorptiometry (DEXA) scanner)