Skip to main content

Table 3 Multivariatea model of the association of polyphenol intakes with TBARs according to the method of handling missing values

From: Association between dietary polyphenols intake and an oxidative stress biomarker: interest of multiple imputation for handling missing covariates and outcomes

Final models   Complete case analysis    Multiple imputation for covariates    Multiple imputation for covariates and outcome   
   (n = 1,112) (n = 2,116) (n = 4,129)
   Estimation se p Estimation se p Estimation se p
Female gender   0.159 0.0282 <0.0001 0.134 0.0215 <0.0001 0.131 0.022 <0.0001
Age (/10 years)   0.044 0.020 0.027 0.023 0.0144 0.12 0.023 0.015 0.12
Intervention group   −0.028 0.022 0.20 −0.0146 0.0158 0.35 −0.015 0.017 0.40
Smoking status at inclusion Never smoked ref   0.13 ref   0.27 ref   0.18
Former smoker 0.029 0.0241   0.025 0.0175   0.0261 0.017  
Smoker 0.069 0.035   0.032 0.027   0.0369 0.026  
Number of dietary records   0.0013 0.0054 0.81 0.0007 0.0039 0.87 0.0007 0.0037 0.83
Energy intake (/1000, kcal/d)   −0.021 0.024 0.38 −0.04 0.017 0.023 −0.040 0.018 0.025
Alcohol intake at inclusion (log) (g/d)   0.0241 0.0082 0.0031 0.026 0.0061 <0.0001 0.023 0.0058 <0.0001
Plasma α-tocophérol (log) (μmol/L)   0.149 0.0414 0.00033 0.172 0.0358 <0.0001 0.177 0.0346 <0.0001
Plasma β-carotene (log) (μmol/L)      −0.034 0.0153 0.025 −0.0341 0.0149 0.024
Plasma Selenium (μmol/L)   0.1320 0.0598 0.027 0.103 0.045 0.021 0.106 0.041 0.010
Plasma Zinc (μmol/L)   0.0151 0.0055 0.0058 0.014 0.0043 0.0016 0.0129 0.0044 0.004
Catechins intake (mg/d) > Q3 - - - 0.0798 0.0272 0.0033 0.034 0.017 0.047
Hydroxybenzoic acids intake (mg/d) > Q3     −0.059 0.0268 0.0272 -   
  1. aThe multivariable models first included eight subclasses of polyphenols (Dihydroflavonols, Proanthocyanidins, Theflavins, Catechins, Flavones, Flavonols, Hydroxybenzoic, Stilbenes) age, gender, intervention group, smoking status at inclusion, height and weight at inclusion, number of dietary records, energy intake, vitamin C, selenium, β-carotene, zinc, α-tocopherol, retinol, and alcohol intake at inclusion
  2. Bold data indicate statistical significance