Anaemia, iron deficiency and inflammation prevalence in children in the Mount Cameroon area and the contribution of inflammatory cytokines on haemoglobin and ferritin concentrations: a cross sectional study

Sama, Sharon Odmia; Taiwe, Germain Sotoing; Teh, Rene Ning; Njume, Gwendolyne Elobe; Chiamo, Seraphine Njuontsop; Sumbele, Irene Ule Ngole

doi:10.1186/s40795-023-00748-3

Table 4 Multiple linear regression analysis examining the influence of socio-demographic factors, clinical factors and inflammatory markers on haemoglobin and ferritin concentrations

From: Anaemia, iron deficiency and inflammation prevalence in children in the Mount Cameroon area and the contribution of inflammatory cytokines on haemoglobin and ferritin concentrations: a cross sectional study

Independent variable	Haemoglobin				Ferritin
	Β	Standard Error (95% CI)	P-value	Model summary	Β	Standard Error (95% CI)	P-value	Model summary
*Socio-demographic factors*
Sex	0.055	0.141 (-0.222–0.332)	0.697	R = 0.269	0.778	0.102 (0.176–1.381)	0.011	R = 0.419
Age in years	0.417	0.102 (0.217–0.616)	< 0.001*	R² = 0.072	-0.268	0.221 (-0.702–0.166)	0.225	R² = 0.176
Enrolment site	0.622	0.158 (0.312–0.932)	< 0.001*	AR² = 0.061	3.198	0.343 (2.525–3.871)	< 0.001*	AR² = 0.166
Education level	0.100	0.096 (-0.089–0.288)	0.300	F = 6.66	-0.197	0.208 (-0.606–0.213)	0.345	F = 18.230
Occupation	-0.025	0.047 (-0.118–0.068)	0.594	P < 0.001	-0.121	0.103 (-0.323–0.081)	0.241	P < 0.001
Family size	0.345	0.125 (0.099–0.591)	0.006		0.208	0.272 (-326–0.743)	0.444
*Clinical factors*
Fever	0.006	0.193 (-0.374–0.387)	0.974	R = 0.159	-1.134	0.455 (-2.029 - -0.238)	0.013	R = 0.295
MP	0.343	0.196 (-0.043–0.728)	0.081	R² = 0.025	-0.949	0.461 (-1.856 - -0.042)	0.040	R² = 0.087
Inflammation	0.005	0.200 (-0.388–0.398)	0.978	AR² = -0.001	1.278	0.470 (0.353–2.203)	0.007	AR² = -0.063
Undernutrition	-0.845	0.939 (-2.698–0.999)	0.366	F = 0.969	3.321	2.210 (-1.030–7.671)	0.134	F = 3.563
Stunting	0.619	0.901 (-1.156–2.394)	0.493	P = 0.454	-3.638	2.122 (-7.816–0.541)	0.088	P = 0.001
Underweight	-0.005	0.636 (-1.256–1.247)	0.994		-2.782	1.496 (-5.728–0,164)	0.064
Wasting	0.557	0.461 (-0.350–1.464)	0.228		-1.565	1.084 (-3.700–0.570)	0.150
*Inflammatory markers*
IL-1β/pg/mL	0.065	0.052 (-0.037–0.167)	0.212	R = 0.157	0.265	0.109 (0.051–0.)	0.016	R = 0.431
IL-6/pg/mL	-0.002	0.001 (-0.004 – < 0.001)	0.026	R² = 0.025	-0.004	0.002 (-0.008 - <0.001)	0.044	R² = 0.186
IL-10/pg/mL	-0.001	< 0.001 (< 0.001–0.001)	0.471	AR² = 0.013	-0.001	0.001 (-0.003 - <0.001)	0.096	AR² = 0.176
IFN-γ/pg/mL	0.004	0.002 (< 0.001–0.008)	0.070	F = 2.152	0.022	0.004 (0.013–0.0.030)	< 0.001*	F = 19.476
TNF-α/pg/mL	0.009	0.008 (-0.005–0.024)	0.217	P = 0.046	0.066	0.016 (0.034–0.097)	< 0.001*	P < 0.001
CRP/ mg/L	-0.029	0.033 (-0.093–0.035)	0.367		0.235	0.069 (0.100–0.370)	0.001

P- value in bold are statistically significant, * statistically significant at P < 0.001
CI = confidence interval; AR² = adjusted R²

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ISSN: 2055-0928

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