Fig. 5

Gene expression in tracheal epithelial cells of ethanol and diallyl disulfide-fed mice. Gene expression was quantified in tracheal epithelial cells of 6-week ethanol- and diallyl disulfide (DADS)-fed mice. a An ethanol-mediated threefold upregulation of gene expression was observed in calcidiol-converting enzyme CYP27B1 gene expression. This upregulation was attenuated by DADS co-exposure. b A non-statistical ethanol-mediated sevenfold upregulation of ethanol-induced VDR gene expression was observed, and the co-exposure of DADS attenuated this upregulation. c A statistically significant increase in gene expression was observed in acetaldehyde-producing CYP2E1 in ethanol-fed mice that was ablated by co-exposure to DADS. d A slight non-statistically significant reduction in CYP24A1 gene expression was observed in the tracheal epithelial cells of chronic ethanol and diallyl disulfide-fed mice (N = 7; *p < 0.05 as compared to the control group, ~p < 0.05 as compared to the ethanol group)