|
Time point
|
Study product
|
Mean (SD)
|
Log-ANOVA
|
|---|
| | | |
Adj. mean ratio
|
95% CI
|
p-value
|
|---|
|
Predose
|
Biolectra
|
0.87 (0.042)
|
1.00
|
(0.98, 1.01)
|
0.5169
|
|
Verla
|
0.87 (0.042)
|
|
60 min
|
Biolectra
|
0.88 (0.043)
|
1.01
|
(1.00, 1.02)
|
0.1991
|
|
Verla
|
0.88 (0.041)
|
|
2 h
|
Biolectra
|
0.89 (0.040)
|
1.03
|
(1.01, 1.04)
|
0.0008*
|
|
Verla
|
0.92 (0.037)
|
|
3 h
|
Biolectra
|
0.85 (0.041)
|
1.03
|
(1.02, 1.04)
|
<.0001*
|
|
Verla
|
0.88 (0.040)
|
|
4 h
|
Biolectra
|
0.88 (0.045)
|
1.03
|
(1.01, 1.04)
|
0.0016*
|
|
Verla
|
0.90 (0.040)
|
|
5 h
|
Biolectra
|
0.87 (0.044)
|
1.03
|
(1.01, 1.04)
|
0.0036*
|
|
Verla
|
0.89 (0.043)
|
|
6 h
|
Biolectra
|
0.86 (0.044)
|
1.02
|
(1.01, 1.04)
|
0.0026*
|
|
Verla
|
0.88 (0.039)
|
|
9 h
|
Biolectra
|
0.89 (0.038)
|
1.02
|
(1.00, 1.03)
|
0.0979
|
|
Verla
|
0.90 (0.048)
|
|
24 h
|
Biolectra
|
0.88 (0.049)
|
1.00
|
(0.99, 1.01)
|
0.8756
|
|
Verla
|
0.88 (0.043)
|
-
CI confidence interval, Mg magnesium, SD standard deviation; Biolectra = Biolectra® Magnesium 300 mg Kapseln; Verla = Magnesium Verla® purKaps. Adjusted mean ratio, 95% CI and p-value are based on an ANOVA model with study product, sequence, period and subject within sequence as considered effects. Statistical significance at a level of 5% is given if the 95% confidence interval of the adjusted mean ratio does not include 1, respectively if the p-value is <0.05. Statistical significance is denoted by an asterisk (*)
