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Table 6 Cytokines

From: Bilberry/red grape juice decreases plasma biomarkers of inflammation and tissue damage in aged men with subjective memory impairment –a randomized clinical trial

  Bilberry/red grape juice (n = 29) Placebo-juice (n = 27)  
Baseline Post-intervention Baseline Post-intervention pMW(Change)
Growth factors (pg/ml)
 EGF 40.5 (5.4–116.8) 23.6 (3.6–104.6) 10.6 (0.6–59.1) 8.5 (0.6–61.1) 0.02*
 FGF2 29.7 (19.9–83.2) 33.0 (20.0–68.0) 21.3 (15.6–26.0) 20.1 (4.8–27.7) 0.26
 GM-CSF 128.1 (40.6–706.3) 120.2 (44.1–268.4) 71.1 (32.9–129.7) 44.5 (22.3–118.3) 0.66
 VEGF 92.4 (20.6–288.8) 124.6 (3.0–212.6) 114.5 (3.0–289.7) 93.3 (3.2–299.1) 0.02*
Chemokines (pg/ml)
 Eotaxin 902.6 (508.4–1999) 958.5 (466.9–2524) 656.7 (602.7–1025) 703.8 (541.7–1028) 0.29
 Fractalkine 66.6 (3.6–405.7) 66.6 (3.6–405.7) 29.0 (3.6–344.2) 29.0 (3.6–344.2) 0.30
 IL8 11.3 (6.6–28.2) 13.0 (8.1–24.3) 8.7 (6.5–13.7) 9.5 (7.8–16.9) 0.09
 CD40ligand 488.5 (417.0–754.6) 513.3 (347.9–608.9) 508.1 (350.8–641.2) 491.4 (461.5–718.5) 0.09
 IP10 1233 (1030–1848) 1118 (974–1442) 989 (833–1346) 1080 (997–1397) 0.13
 MCP 409.2 (378.6–454.6) 398.4 (385.9–422.6) 415.4 (396.6–515.6) 450.8 (401.3–523.0) 0.55
 MIP1b 110.6 (99.5–306.4) 131.1 (61.7–343.2) 72.1 (52.6–142.9) 93.7 (50.0–137.7) 0.02*
Interleukins (pg/ml)
 IL4 0.6 [0.6, 317.2] 0.6 [0.6, 353.5] 0.6 [0.6, 620.8] 0.6 [0.6, 210.3] 0.76
 IL6 38.1 (4.0–164.2) 24.2 (5.4–170.4) 17.1 (5.2–44.6) 17.6 (4.0–49.9) 0.04*
 IL7 3.7 (3.7–35.7) 3.7 (3.7–25.9) 0.6 (0.0–0.0) 0.6 (0.0–0.0) 0.17
 IL9 1.2 (0.6–7.7) 0.6 (0.6–9.7) 0.6 (0.6–4.8) 0.6 (0.6–5.5) 0.05*
 IL10 1.1 (0.7–4.9) 0.7 (0.7–1.9) 0.7 (0.7–3.3) 0.8 (0.7–3.1) 0.05*
 IL12 13.6 (0.6–80.2) 7.4 (0.6–59.7) 1.9 (0.6–15.1) 1.8 (0.6–17.7) 0.15
 IL13 2.4 (0.6–25.2) 0.6 (0.6–39.3) 0.6 (0.6–9.9) 0.6 (0.6–5.5) 0.30
 IL17 11.2 (4.7–45.7) 13.5 (4.5–39.6) 10.8 (1.5–29.9) 11.7 (1.6–23.2) 0.17
TNF α 8.2 (5.1–24.8) 7.5 (6.1–24.8) 6.0 (5.0–9.0) 6.8 (4.5–9.4) 0.04*
IFN γ 17.6 (5.7–134.7) 15.7 (6.4–103.6) 9.0 (2.0–17.9) 9.7 (2.3–15.6) 0.06
  1. Data is presented as median for baseline and post intervention with the corresponding 95%CL (lower, upper) or [min, max]. P values are given for the comparison of changes between the groups (Mann Whitney test). EGF epidermal growth factor, FGF fibroblast growth factor, GM-CSF Granulocyte-macrophage colony-stimulating factor, VEGF Vascular endothelial growth factor, IP immunoprotein, MCP monocyte chemotactic protein, MIP Macrophage Inflammatory Protein, IL interleukin, TNF tumor necrosis factor, IFN Interferon. *p ≤ 0.05