Reisberg B, Gauthier S. Current evidence for subjective cognitive impairment (SCI) as the pre-mild cognitive impairment (MCI) stage of subsequently manifest Alzheimer's disease. Int Psychogeriatr. 2008;20(1):1–16. https://doi.org/10.1017/S1041610207006412.
Article
PubMed
Google Scholar
Reisberg B, Prichep L, Mosconi L, John ER, Glodzik-Sobanska L, Boksay I, et al. The pre-mild cognitive impairment, subjective cognitive impairment stage of Alzheimer's disease. Alzheimers Dement. 2008;4(1 Suppl 1):S98–S108. https://doi.org/10.1016/j.jalz.2007.11.017.
Article
PubMed
Google Scholar
Gauthier S, Reisberg B, Zaudig M, Petersen RC, Ritchie K, Broich K, et al. Mild cognitive impairment. Lancet. 2006;367(9518):1262–70. https://doi.org/10.1016/S0140-6736(06)68542-5.
Article
PubMed
Google Scholar
Feldman HH, Jacova C. Mild cognitive impairment. Am J Geriatr Psychiatry. 2005;13(8):645–55. https://doi.org/10.1097/00019442-200508000-00003.
Article
PubMed
Google Scholar
Gjøra L, Strand BH, Bergh S, Borza T, Brækhus A, Engedal K, et al. Current and future prevalence estimates of mild cognitive impairment, dementia, and its subtypes in a population-based sample of people 70 years and older in Norway: the HUNT study. J Alzheimers Dis. 2021;79(3):1213–26. https://doi.org/10.3233/JAD-201275.
Article
PubMed
PubMed Central
Google Scholar
Scheltens P, Blennow K, Breteler MM, de Strooper B, Frisoni GB, Salloway S, et al. Alzheimer's disease. Lancet. 2016;388(10043):505–17. https://doi.org/10.1016/S0140-6736(15)01124-1.
Article
CAS
PubMed
Google Scholar
Lovell MA, Markesbery WR. Oxidative DNA damage in mild cognitive impairment and late-stage Alzheimer's disease. Nucleic Acids Res. 2007;35(22):7497–504. https://doi.org/10.1093/nar/gkm821.
Article
CAS
PubMed
PubMed Central
Google Scholar
Loef M, Walach H. Fruit, vegetables and prevention of cognitive decline or dementia: a systematic review of cohort studies. J Nutr Health Aging. 2012;16(7):626–30. https://doi.org/10.1007/s12603-012-0097-x.
Article
CAS
PubMed
Google Scholar
Andrade S, Ramalho MJ, Loureiro JA, Pereira MDC. Natural Compounds for Alzheimer's Disease Therapy: A Systematic Review of Preclinical and Clinical Studies. Int J Mol Sci. 2019;20:92313. https://doi.org/10.3390/ijms20092313.
Article
CAS
Google Scholar
Travica N, D'Cunha NM, Naumovski N, Kent K, Mellor DD, Firth J, et al. The effect of blueberry interventions on cognitive performance and mood: a systematic review of randomized controlled trials. Brain Behav Immun. 2020;85:96–105. https://doi.org/10.1016/j.bbi.2019.04.001.
Article
CAS
PubMed
Google Scholar
Nurk E, Refsum H, Drevon CA, Tell GS, Nygaard HA, Engedal K, et al. Intake of flavonoid-rich wine, tea, and chocolate by elderly men and women is associated with better cognitive test performance. J Nutr. 2009;139(1):120–7. https://doi.org/10.3945/jn.108.095182.
Article
CAS
PubMed
Google Scholar
Bickford PC, Gould T, Briederick L, Chadman K, Pollock A, Young D, et al. Antioxidant-rich diets improve cerebellar physiology and motor learning in aged rats. Brain Res. 2000;866(1–2):211–7. https://doi.org/10.1016/S0006-8993(00)02280-0.
Article
CAS
PubMed
Google Scholar
Fang EF, Hou Y, Palikaras K, Adriaanse BA, Kerr JS, Yang B, et al. Mitophagy inhibits amyloid-beta and tau pathology and reverses cognitive deficits in models of Alzheimer's disease. Nat Neurosci. 2019;22(3):401–12. https://doi.org/10.1038/s41593-018-0332-9.
Article
CAS
PubMed
PubMed Central
Google Scholar
McGuire SO, Sortwell CE, Shukitt-Hale B, Joseph JA, Hejna MJ, Collier TJ. Dietary supplementation with blueberry extract improves survival of transplanted dopamine neurons. Nutr Neurosci. 2006;9(5–6):251–8. https://doi.org/10.1080/10284150601086134.
Article
CAS
PubMed
Google Scholar
Joseph JA, Denisova NA, Arendash G, Gordon M, Diamond D, Shukitt-Hale B, et al. Blueberry supplementation enhances signaling and prevents behavioral deficits in an Alzheimer disease model. Nutr Neurosci. 2003;6(3):153–62. https://doi.org/10.1080/1028415031000111282.
Article
CAS
PubMed
Google Scholar
Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov. 2006;5(6):493–506. https://doi.org/10.1038/nrd2060.
Article
CAS
PubMed
Google Scholar
Pearson KJ, Baur JA, Lewis KN, Peshkin L, Price NL, Labinskyy N, et al. Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab. 2008;8(2):157–68. https://doi.org/10.1016/j.cmet.2008.06.011.
Article
CAS
PubMed
PubMed Central
Google Scholar
Park YK, Kim JS, Kang MH. Concord grape juice supplementation reduces blood pressure in Korean hypertensive men: double-blind, placebo controlled intervention trial. Biofactors. 2004;22(1–4):145–7. https://doi.org/10.1002/biof.5520220128.
Article
CAS
PubMed
Google Scholar
Park YK, Lee SH, Park E, Kim JS, Kang MH. Changes in antioxidant status, blood pressure, and lymphocyte DNA damage from grape juice supplementation. Ann N Y Acad Sci. 2009;1171:385–90, 1. https://doi.org/10.1111/j.1749-6632.2009.04907.x.
Article
CAS
PubMed
Google Scholar
Karlsen A, Paur I, Bohn SK, Sakhi AK, Borge GI, Serafini M, et al. Bilberry juice modulates plasma concentration of NF-kappaB related inflammatory markers in subjects at increased risk of CVD. Eur J Nutr. 2010;49(6):345–55. https://doi.org/10.1007/s00394-010-0092-0.
Article
CAS
PubMed
Google Scholar
Karlsen A, Retterstol L, Laake P, Paur I, Kjolsrud-Bohn S, Sandvik L, et al. Anthocyanins inhibit nuclear factor-kappaB activation in monocytes and reduce plasma concentrations of pro-inflammatory mediators in healthy adults. J Nutr. 2007;137(8):1951–4. https://doi.org/10.1093/jn/137.8.1951.
Article
CAS
PubMed
Google Scholar
Habanova M, Saraiva JA, Haban M, Schwarzova M, Chlebo P, Predna L, et al. Intake of bilberries (Vaccinium myrtillus L.) reduced risk factors for cardiovascular disease by inducing favorable changes in lipoprotein profiles. Nutr Res. 2016;36(12):1415–22. https://doi.org/10.1016/j.nutres.2016.11.010.
Article
CAS
PubMed
Google Scholar
de Mello VD, Lankinen MA, Lindström J, Puupponen-Pimiä R, Laaksonen DE, Pihlajamäki J, et al. Fasting serum hippuric acid is elevated after bilberry (Vaccinium myrtillus) consumption and associates with improvement of fasting glucose levels and insulin secretion in persons at high risk of developing type 2 diabetes. Mol Nutr Food Res. 2017;61:9. https://doi.org/10.1002/mnfr.201700019.
Article
CAS
Google Scholar
Tjelle TE, Holtung L, Bøhn SK, Aaby K, Thoresen M, Wiik SÅ, et al. Polyphenol-rich juices reduce blood pressure measures in a randomised controlled trial in high normal and hypertensive volunteers. Br J Nutr. 2015;114(7):1054–63. https://doi.org/10.1017/S0007114515000562.
Article
CAS
PubMed
Google Scholar
Biedermann L, Mwinyi J, Scharl M, Frei P, Zeitz J, Kullak-Ublick GA, et al. Bilberry ingestion improves disease activity in mild to moderate ulcerative colitis - an open pilot study. J Crohn's Colitis. 2013;7(4):271–9. https://doi.org/10.1016/j.crohns.2012.07.010.
Article
Google Scholar
Lehtonen HM, Suomela JP, Tahvonen R, Yang B, Venojärvi M, Viikari J, et al. Different berries and berry fractions have various but slightly positive effects on the associated variables of metabolic diseases on overweight and obese women. Eur J Clin Nutr. 2011;65(3):394–401. https://doi.org/10.1038/ejcn.2010.268.
Article
CAS
PubMed
Google Scholar
Silva S, Costa EM, Veiga M, Morais RM, Calhau C, Pintado M. Health promoting properties of blueberries: a review. Crit Rev Food Sci Nutr. 2020;60(2):181–200. https://doi.org/10.1080/10408398.2018.1518895.
Article
PubMed
Google Scholar
Fray PJ, Robbins TW. CANTAB battery: proposed utility in neurotoxicology. Neurotoxicol Teratol. 1996;18(4):499–504. https://doi.org/10.1016/0892-0362(96)00027-X.
Article
CAS
PubMed
Google Scholar
Krikorian R, Nash TA, Shidler MD, Shukitt-Hale B, Joseph JA. Concord grape juice supplementation improves memory function in older adults with mild cognitive impairment. Br J Nutr. 2010;103(5):730–4. https://doi.org/10.1017/S0007114509992364.
Article
CAS
PubMed
Google Scholar
Lamport DJ, Lawton CL, Merat N, Jamson H, Myrissa K, Hofman D, et al. Concord grape juice, cognitive function, and driving performance: a 12-wk, placebo-controlled, randomized crossover trial in mothers of preteen children. Am J Clin Nutr. 2016;103(3):775–83. https://doi.org/10.3945/ajcn.115.114553.
Article
CAS
PubMed
Google Scholar
Krikorian R, Shidler MD, Nash TA, Kalt W, Vinqvist-Tymchuk MR, Shukitt-Hale B, et al. Blueberry supplementation improves memory in older adults. J Agric Food Chem. 2010;58(7):3996–4000. https://doi.org/10.1021/jf9029332.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bensalem J, Dudonné S, Etchamendy N, Pellay H, Amadieu C, Gaudout D, et al. Polyphenols from grape and blueberry improve episodic memory in healthy elderly with lower level of memory performance: a Bicentric double-blind, randomized, placebo-controlled clinical study. J Gerontol A Biol Sci Med Sci. 2019;74(7):996–1007. https://doi.org/10.1093/gerona/gly166.
Article
CAS
PubMed
Google Scholar
Engedal K, Haugen P, Gilje K, Laake P. Efficacy of short mental tests in the detection of mental impairment in old age. Compr Gerontol A. 1988;2(2):87–93.
CAS
PubMed
Google Scholar
Carlsen MH, Lillegaard IT, Karlsen A, Blomhoff R, Drevon CA, Andersen LF. Evaluation of energy and dietary intake estimates from a food frequency questionnaire using independent energy expenditure measurement and weighed food records. Nutr J. 2010;9(1):37. https://doi.org/10.1186/1475-2891-9-37.
Article
PubMed
PubMed Central
Google Scholar
Egerhazi A, Berecz R, Bartok E, Degrell I. Automated neuropsychological test battery (CANTAB) in mild cognitive impairment and in Alzheimer's disease. Prog Neuro-Psychopharmacol Biol Psychiatry. 2007;31(3):746–51. https://doi.org/10.1016/j.pnpbp.2007.01.011.
Article
Google Scholar
Matthews C, Kløve H. Instruction manual for the adult neuropsychology test battery. Wisconsin: University of Wisconsin Medical School; 1964.
Google Scholar
Kløve H. CLINICAL NEUROPSYCHOLOGY. Med Clin North Am. 1963;47:1647–58, 6. https://doi.org/10.1016/S0025-7125(16)33515-5.
Article
PubMed
Google Scholar
Lafayette: Grooved Pegboard: User’s Manual. IN: Lafayette Instrument Company. 2003.
Google Scholar
Bastani NE, Gundersen TE, Blomhoff R. Determination of 8-epi PGF(2alpha) concentrations as a biomarker of oxidative stress using triple-stage liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom. 2009;23(18):2885–90. https://doi.org/10.1002/rcm.4197.
Article
CAS
PubMed
Google Scholar
Bohn SK, Myhrstad MC, Thoresen M, Holden M, Karlsen A, Tunheim SH, et al. Blood cell gene expression associated with cellular stress defense is modulated by antioxidant-rich food in a randomised controlled clinical trial of male smokers. BMC Med. 2010;8(54):1. https://doi.org/10.1186/1741-7015-8-54.
Article
CAS
Google Scholar
Erlund I, Alfthan G, Siren H, Ariniemi K, Aro A. Validated method for the quantitation of quercetin from human plasma using high-performance liquid chromatography with electrochemical detection. J Chromatogr B Biomed Sci Appl. 1999;727(1–2):179–89. https://doi.org/10.1016/S0378-4347(99)00049-3.
Article
CAS
PubMed
Google Scholar
Kilkkinen A, Erlund I, Virtanen MJ, Alfthan G, Ariniemi K, Virtamo J. Serum enterolactone concentration and the risk of coronary heart disease in a case-cohort study of Finnish male smokers. Am J Epidemiol. 2006;163(8):687–93. https://doi.org/10.1093/aje/kwj080.
Article
PubMed
Google Scholar
Oikarinen SI, Erlund I, Mutanen M. Tumour formation in multiple intestinal neoplasia (ApcMin/+) mice fed with filtered or unfiltered coffee. Food Nutr Res. 2007;51:167–73, 4. https://doi.org/10.1080/17482970701757119.
Article
Google Scholar
Lamport DJ, Dye L, Wightman JD, Lawton CL. The effects of flavonoid and other polyphenol consumption on cognitive performance: a systematic research review of human experimental and epidemiological studies. Nutrition and Aging. 2012;1(1):5–25. https://doi.org/10.3233/NUA-2012-0002.
Article
Google Scholar
Boespflug EL, Eliassen JC, Dudley JA, Shidler MD, Kalt W, Summer SS, et al. Enhanced neural activation with blueberry supplementation in mild cognitive impairment. Nutr Neurosci. 2018;21(4):297–305. https://doi.org/10.1080/1028415X.2017.1287833.
Article
CAS
PubMed
Google Scholar
Kolehmainen M, Mykkänen O, Kirjavainen PV, Leppänen T, Moilanen E, Adriaens M, et al. Bilberries reduce low-grade inflammation in individuals with features of metabolic syndrome. Mol Nutr Food Res. 2012;56(10):1501–10. https://doi.org/10.1002/mnfr.201200195.
Article
CAS
PubMed
Google Scholar
Newcombe EA, Camats-Perna J, Silva ML, Valmas N, Huat TJ, Medeiros R. Inflammation: the link between comorbidities, genetics, and Alzheimer’s disease. J Neuroinflammation. 2018;15(1):276. https://doi.org/10.1186/s12974-018-1313-3.
Article
CAS
PubMed
PubMed Central
Google Scholar
Trapero I, Cauli O. Interleukin 6 and cognitive dysfunction. Metab Brain Dis. 2014;29(3):593–608. https://doi.org/10.1007/s11011-014-9551-2.
Article
CAS
PubMed
Google Scholar
Angelopoulos P, Agouridaki H, Vaiopoulos H, Siskou E, Doutsou K, Costa V, et al. Cytokines in Alzheimer's disease and vascular dementia. Int J Neurosci. 2008;118(12):1659–72. https://doi.org/10.1080/00207450701392068.
Article
CAS
PubMed
Google Scholar
Baranowska-Bik A, Bik W, Wolinska-Witort E, Martynska L, Chmielowska M, Barcikowska M, et al. Plasma beta amyloid and cytokine profile in women with Alzheimer's disease. Neuro Endocrinol Lett. 2008;29(1):75–9.
CAS
PubMed
Google Scholar
Lee KS, Chung JH, Choi TK, Suh SY, Oh BH, Hong CH. Peripheral cytokines and chemokines in Alzheimer's disease. Dement Geriatr Cogn Disord. 2009;28(4):281–7. https://doi.org/10.1159/000245156.
Article
CAS
PubMed
Google Scholar
Ray S, Britschgi M, Herbert C, Takeda-Uchimura Y, Boxer A, Blennow K, et al. Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins. Nat Med. 2007;13(11):1359–62. https://doi.org/10.1038/nm1653.
Article
CAS
PubMed
Google Scholar
Smits HA, Rijsmus A, van Loon JH, Wat JW, Verhoef J, Boven LA, et al. Amyloid-beta-induced chemokine production in primary human macrophages and astrocytes. J Neuroimmunol. 2002;127(1–2):160–8. https://doi.org/10.1016/S0165-5728(02)00112-1.
Article
CAS
PubMed
Google Scholar
Proescholdt MA, Jacobson S, Tresser N, Oldfield EH, Merrill MJ. Vascular endothelial growth factor is expressed in multiple sclerosis plaques and can induce inflammatory lesions in experimental allergic encephalomyelitis rats. J Neuropathol Exp Neurol. 2002;61(10):914–25. https://doi.org/10.1093/jnen/61.10.914.
Article
CAS
PubMed
Google Scholar
Strle K, Zhou JH, Shen WH, Broussard SR, Johnson RW, Freund GG, et al. Interleukin-10 in the brain. Crit Rev Immunol. 2001;21(5):427–49. https://doi.org/10.1615/CritRevImmunol.v21.i5.20.
Article
CAS
PubMed
Google Scholar
Kumar A, Naidu PS, Seghal N, Padi SSV. Neuroprotective effects of resveratrol against Intracerebroventricular colchicine-induced cognitive impairment and oxidative stress in rats. Pharmacology. 2007;79(1):17–26. https://doi.org/10.1159/000097511.
Article
CAS
PubMed
Google Scholar
Goulart M, Pisamiglio DS, MÖller GB, Dani C, Alves FD, Bock PM, et al. Effects of grape juice consumption on muscle fatigue and oxidative stress in judo athletes: a randomized clinical trial. An Acad Bras Cienc. 2020;92(4):e20191551. https://doi.org/10.1590/0001-3765202020191551.
Article
CAS
PubMed
Google Scholar
Koli R, Erlund I, Jula A, Marniemi J, Mattila P, Alfthan G. Bioavailability of various polyphenols from a diet containing moderate amounts of berries (dagger). J Agric Food Chem. 2010;58(7):3927–32. https://doi.org/10.1021/jf9024823.
Article
CAS
PubMed
Google Scholar
Rutledge GA, Fisher DR, Miller MG, Kelly ME, Bielinski DF, Shukitt-Hale B. The effects of blueberry and strawberry serum metabolites on age-related oxidative and inflammatory signaling in vitro. Food Funct. 2019;10(12):7707–13. https://doi.org/10.1039/C9FO01913H.
Article
CAS
PubMed
PubMed Central
Google Scholar
Griñán-Ferré C, Bellver-Sanchis A, Izquierdo V, Corpas R, Roig-Soriano J, Chillón M, et al. The pleiotropic neuroprotective effects of resveratrol in cognitive decline and Alzheimer’s disease pathology: from antioxidant to epigenetic therapy. Ageing Res Rev. 2021;67:101271. https://doi.org/10.1016/j.arr.2021.101271.
Article
CAS
PubMed
Google Scholar
Mykkänen OT, Huotari A, Herzig KH, Dunlop TW, Mykkänen H, Kirjavainen PV. Wild blueberries (Vaccinium myrtillus) alleviate inflammation and hypertension associated with developing obesity in mice fed with a high-fat diet. PLoS One. 2014;9(12):e114790. https://doi.org/10.1371/journal.pone.0114790.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wendeln AC, Degenhardt K, Kaurani L, Gertig M, Ulas T, Jain G, et al. Innate immune memory in the brain shapes neurological disease hallmarks. Nature. 2018;556(7701):332–8. https://doi.org/10.1038/s41586-018-0023-4.
Article
CAS
PubMed
PubMed Central
Google Scholar
Schwartz M, Ziv Y. Immunity to self and self-maintenance: a unified theory of brain pathologies. Trends Immunol. 2008;29(5):211–9. https://doi.org/10.1016/j.it.2008.01.003.
Article
CAS
PubMed
Google Scholar
Carlsen MH, Halvorsen BL, Holte K, Bohn SK, Dragland S, Sampson L, et al. The total antioxidant content of more than 3100 foods, beverages, spices, herbs and supplements used worldwide. Nutr J. 2010;9(1):3. https://doi.org/10.1186/1475-2891-9-3.
Article
PubMed
PubMed Central
Google Scholar
Johansson L, Andersen LF. Who eats 5 a day?: intake of fruits and vegetables among Norwegians in relation to gender and lifestyle. J Am Diet Assoc. 1998;98(6):689–91. https://doi.org/10.1016/S0002-8223(98)00156-4.
Article
CAS
PubMed
Google Scholar