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Table 2 Expression of studied genes in BT-474 cell line

From: Docosahexaenoic acid (DHA) impairs hypoxia-induced cellular and exosomal overexpression of immune-checkpoints and immunomodulatory molecules in different subtypes of breast cancer cells

BT-474

Normoxic

Hypoxic

Treated with DHA

Treated with CoCl2

Treated with DHA and CoCl2

 

Fold change

P-value *

Fold change

P-value **

Fold change

P-value***

CD39

-2674

< 0.0001

1.657001

< 0.0001

-277

< 0.0001

CD73

-567.85

< 0.0001

1.599488

< 0.0001

-5.85

< 0.0001

CD47

-18.00018

< 0.0001

1.046463

< 0.0001

-96.11

< 0.0001

CD80

-211.014

< 0.0001

2.024291

< 0.0001

-57.74

< 0.0001

PD-L1

-347.101

< 0.0001

1.674481

< 0.0001

-4

< 0.0001

B7-H3

-15.156

< 0.0001

1.320132

0.0001

-4.25

< 0.0001

B7-H4

-490.196

< 0.0001

1.548227

< 0.0001

-1.99

< 0.0001

  1. *: compared control with DHA treated group
  2. **: compared control with CoCl2 treated group
  3. ***: compared CoCl2 treated group with DHA + CoCl2 treated group
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BMC Nutrition

ISSN: 2055-0928

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