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Table 3 Expression of studied genes in MDA-MB-231 cell line

From: Docosahexaenoic acid (DHA) impairs hypoxia-induced cellular and exosomal overexpression of immune-checkpoints and immunomodulatory molecules in different subtypes of breast cancer cells

MDA-MB-231

Normoxic

Hypoxic

Treated with DHA

Treated with CoCl2

Treated with DHA and CoCl2

 

Fold change

P-value*

Fold change

P-value**

Fold change

P-value***

CD39

-21.54

< 0.0001

1.931994

< 0.0001

-3.70

< 0.0001

CD73

-3.2329

0.0001

13.36898

< 0.0001

-5.25

< 0.0001

CD47

-1.2378

0.0324

19.86097

< 0.0001

-1.78

< 0.0001

CD80

-2.1281

0.0006

18.38235

< 0.0001

-6.32

< 0.0001

PD-L1

-2.4426

< 0.0001

5.52975

< 0.0001

-10.27

< 0.0001

B7-H3

-40.98

< 0.0001

2.191541

< 0.0001

-24.91

< 0.0001

B7-H4

-2.4056

< 0.0001

13.7931

< 0.0001

-16.91

< 0.0001

  1. *: compared control with DHA treated group
  2. **: compared control with CoCl2 treated group
  3. ***: compared CoCl2 treated group with DHA + CoCl2 treated group
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BMC Nutrition

ISSN: 2055-0928

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