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Table 6 Expression of studied genes in exosomes- derived BT-474 cell line

From: Docosahexaenoic acid (DHA) impairs hypoxia-induced cellular and exosomal overexpression of immune-checkpoints and immunomodulatory molecules in different subtypes of breast cancer cells

Exo-BT-474

Normoxic

Hypoxic

Treated with DHA

Treated with CoCl2

Treated with DHA and CoCl2

 

Fold change

P-value*

Fold change

P-value**

Fold change

P-value***

CD39

-1.8856

< 0.0001

1.924928

< 0.0001

-2.41

< 0.0001

CD73

-8.98

< 0.0001

1.85701

< 0.0001

-2.54

< 0.0001

CD47

-1.39

0.0016

-1.21

0.0240

-1.07

0.7316

CD80

-1.79

0.0012

2.309469

< 0.0001

-3.02

< 0.0001

PD-L1

-1.19

0.1186

1.869858

< 0.0001

-2.20

< 0.0001

B7-H3

-2.064

< 0.0001

2.184837

< 0.0001

-3.44

< 0.0001

B7-H4

-2.428

< 0.0001

1.897533

< 0.0001

-3.66

< 0.0001

  1. *: compared control with DHA treated group
  2. **: compared control with CoCl2 treated group
  3. ***: compared CoCl2 treated group with DHA + CoCl2 treated group
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BMC Nutrition

ISSN: 2055-0928

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