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Table 7 Expression of studied genes in exosomes- derived MDA-MB-231 cell line

From: Docosahexaenoic acid (DHA) impairs hypoxia-induced cellular and exosomal overexpression of immune-checkpoints and immunomodulatory molecules in different subtypes of breast cancer cells

Exo-MDA-MB-231

Normoxic

Hypoxic

Treated with DHA

Treated with CoCl2

Treated with DHA and CoCl2

 

Fold change

P-value*

Fold change

P-value**

Fold change

P-value***

CD39

-5,376,344

< 0.0001

1.364815

< 0.0001

-6,170,426

< 0.0001

CD73

-116.6

< 0.0001

1.920861

< 0.0001

-8.86

< 0.0001

CD47

-4149.3

< 0.0001

-2695.4

< 0.0001

-1.18

< 0.0001

CD80

-10,416

< 0.0001

1.739433

< 0.0001

-5516

< 0.0001

PD-L1

-7246.3

< 0.0001

1.488982

< 0.0001

-1021

< 0.0001

B7-H3

-16181.2

< 0.0001

1.044386

< 0.0001

-2373

< 0.0001

B7-H4

-6711.4

< 0.0001

1.465201

< 0.0001

-199

< 0.0001

  1. *: compared control with DHA treated group
  2. **: compared control with CoCl2 treated group
  3. ***: compared CoCl2 treated group with DHA + CoCl2 treated group
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BMC Nutrition

ISSN: 2055-0928

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