OBrien K, Breyne K, Ughetto S, Laurent LC, Breakefield XO. RNA delivery by extracellular vesicles in mammalian cells and its applications. Nat Rev Mol Cell Biol. 2020;21(10):585–606.
Article
Google Scholar
Friedman RC, Farh KK, Burge CB, Bartel DP. Most mammalian mRNAs are conserved targets of microRNAs. Genome Res. 2009;19(1):92–105.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kozomara A, Birgaoanu M, Griffiths-Jones S. miRBase: from microRNA sequences to function. Nucleic Acids Res. 2019;47(D1):D155–D62.
Article
CAS
PubMed
Google Scholar
Wu Q, Song R, Ortogero N, Zheng H, Evanoff R, Small CL, et al. The RNase III enzyme DROSHA is essential for microRNA production and spermatogenesis. J Biol Chem. 2012;287(30):25173–90.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bernstein E, Kim SY, Carmell MA, Murchison EP, Alcorn H, Li MZ, et al. Dicer is essential for mouse development. Nat Genet. 2003;35(3):215–7.
Article
CAS
PubMed
Google Scholar
Schirle NT, Sheu-Gruttadauria J, MacRae IJ. Structural basis for microRNA targeting. Science. 2014;346(6209):608–13.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ricci EP, Limousin T, Soto-Rifo R, Rubilar PS, Decimo D, Ohlmann T. miRNA repression of translation in vitro takes place during 43S ribosomal scanning. Nucleic Acids Res. 2013;41(1):586–98.
Article
CAS
PubMed
Google Scholar
Lasser C, Alikhani VS, Ekstrom K, Eldh M, Paredes PT, Bossios A, et al. Human saliva, plasma and breast milk exosomes contain RNA: uptake by macrophages. J Transl Med. 2011;9:9.
Article
PubMed
PubMed Central
Google Scholar
Izumi H, Kosaka N, Shimizu T, Sekine K, Ochiya T, Takase M. Bovine milk contains microRNA and messenger RNA that are stable under degradative conditions. J Dairy Sci. 2012;95(9):4831–41.
Article
CAS
PubMed
Google Scholar
Sun J, Aswath K, Schroeder SG, Lippolis JD, Reinhardt TA, Sonstegard TS. MicroRNA expression profiles of bovine milk exosomes in response to Staphylococcus aureus infection. BMC Genomics. 2015;16(1):806.
Article
CAS
PubMed
PubMed Central
Google Scholar
Leiferman A, Shu J, Upadhyaya B, Cui J, Zempleni J. Storage of extracellular vesicles in human milk, and microRNA profiles in human milk exosomes and infant formulas. J Pediatr Gastroenterol Nutr. 2019;69(2):235–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Escrevente C, Keller S, Altevogt P, Costa J. Interaction and uptake of exosomes by ovarian cancer cells. BMC Cancer. 2011;11:108.
Article
CAS
PubMed
PubMed Central
Google Scholar
Baier SR, Nguyen C, Xie F, Wood JR, Zempleni J. MicroRNAs are absorbed in biologically meaningful amounts from nutritionally relevant doses of cow’s milk and affect gene expression in peripheral blood mononuclear cells, HEK-293 kidney cell cultures, and mouse livers. J Nutr. 2014;144:1495–500.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wolf T, Baier SR, Zempleni J. The intestinal transport of bovine milk exosomes is mediated by endocytosis in human colon carcinoma caco-2 cells and rat small intestinal IEC-6 cells. J Nutr. 2015;145:2201–6.
Article
CAS
PubMed
PubMed Central
Google Scholar
Manca S, Upadhyaya B, Mutai E, Desaulniers AT, Cederberg RA, White BR, et al. Milk exosomes are bioavailable and distinct microRNA cargos have unique tissue distribution patterns. Sci Rep. 2018;8(1):11321.
Article
PubMed
PubMed Central
Google Scholar
Zempleni J, Sukreet S, Zhou F, Wu D, Mutai E. Milk-derived exosomes and metabolic regulation. Annu Rev Anim Biosci. 2019;15(7):245–62.
Article
Google Scholar
Aguilar-Lozano A, Baier SR, Grove R, Shu J, Giraud D, Mercer KE, et al. Concentrations of purine metabolites are elevated in fluids from adults and infants and in livers from mice fed diets depleted of bovine milk exosomes and their RNA cargos. J Nutr. 2018;148:1886–94.
Article
PubMed
PubMed Central
Google Scholar
Leiferman A, Shu J, Grove R, Cui J, Adamec J, Zempleni J. A diet defined by its content of bovine milk exosomes and their RNA cargos has moderate effects on gene expression, amino acid profiles and grip strength in skeletal muscle in C57BL/6 mice. J Nutr Biochem. 2018;59:123–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wu D, Kittana H, Shu J, Kachman SD, Cui J, Ramer-Tait AE, et al. Dietary depletion of milk exosomes and their microRNA cargos elicits a depletion of miR-200a-3p and elevated intestinal inflammation and CXCL9 expression in Mdr1a−/− mice. Curr Dev Nutr. 2019;3:122.
Article
Google Scholar
Zhou F, Paz HA, Sadri M, Cui J, Kachman SD, Fernando SC, et al. Dietary bovine bilk exosomes elicit changes in bacterial communities in C57BL/6 mice. Am J Physiol Gastrointest Liver Physiol. 2019;317(11):G618–G24.
Article
CAS
PubMed
PubMed Central
Google Scholar
Sadri M, Shu J, Kachman SD, Cui J, Zempleni J. Milk exosomes and microRNAs cross the placenta and promote embryo survival in mice. Reproduction. 2020;160:501–9.
Article
CAS
PubMed
Google Scholar
Li B, Hock A, Wu RY, Minich A, Botts SR, Lee C, et al. Bovine milk-derived exosomes enhance goblet cell activity and prevent the development of experimental necrotizing enterocolitis. PLoS One. 2019;14(1):e0211431.
Article
CAS
PubMed
PubMed Central
Google Scholar
Alsaweed M, Lai CT, Hartmann PE, Geddes DT, Kakulas F. Human milk miRNAs primarily originate from the mammary gland resulting in unique miRNA profiles of fractionated milk. Sci Rep. 2016;6:20680.
Article
CAS
PubMed
PubMed Central
Google Scholar
Melnik BC, Stremmel W, Weiskirchen R, John SM, Schmitz G. Exosome-derived microRNAs of human milk and their effects on infant health and development. Biomolecules. 2021;11(6):851
Technavio R. Soy-based infant formula market to grow by USD 277.69 million, at 3% CAGR during 2019-2023 Toronto, ON (Canada): Technavio; 2019 [Available from: https://www.businesswire.com/news/home/20190626005474/en/.
Google Scholar
Kent G. Regulating fatty acids in infant formula: critical assessment of U.S. policies and practices. Int Breastfeed J. 2014;9(1):2.
Article
PubMed
PubMed Central
Google Scholar
Vandenplas Y, Zakharova I, Dmitrieva Y. Oligosaccharides in infant formula: more evidence to validate the role of prebiotics. Brit J Nutr. 2015;113(9):1339–44.
Article
CAS
PubMed
Google Scholar
Sharon N, Lis H. Lectins: cell-agglutinating and sugar-specific proteins. Science. 1972;177(4053):949–59.
Article
CAS
PubMed
Google Scholar
Shtam TA, Burdakov VS, Landa SB, Naryzhny SN, Bairamukov VY, Malek AV, et al. Aggregation by lectin-methodical approach for effective isolation of exosomes from cell culture supernatant for proteome profiling. Tsitologiia. 2017;59(1):5–12.
CAS
PubMed
Google Scholar
Brandon DL, Friedman M. Immunoassays of soy proteins. J Agric Food Chem. 2002;50(22):6635–42.
Article
CAS
PubMed
Google Scholar
Williams C, Royo F, Aizpurua-Olaizola O, Pazos R, Boons GJ, Reichardt NC, et al. Glycosylation of extracellular vesicles: current knowledge, tools and clinical perspectives. J Extracell Vesicles. 2018;7(1):1442985.
Article
PubMed
PubMed Central
Google Scholar
Pusztai A, Grant G. Assessment of lectin inactivation by heat and digestion. Methods Mol Med. 1998;9:505–14.
CAS
PubMed
Google Scholar
Sun X, Wang C, Wang H, Guo M. Effects of processing on structure and thermal properties of powdered preterm infant formula. J Food Sci. 2018;83(6):1685–94.
Article
CAS
PubMed
Google Scholar
Zhou Q, Li M, Wang X, Li Q, Wang T, Zhu Q, et al. Immune-related microRNAs are abundant in breast milk exosomes. Int J Biol Sci. 2012;8(1):118–23.
Article
CAS
PubMed
Google Scholar
Sukreet S, Pereira Braga C, An TT, Adamec J, Cui J, Trible B, et al. Isolation of extracellular vesicles from byproducts of cheese making by tangential flow filtration yields heterogeneous fractions of nanoparticles. J Dairy Sci. 2021;104:9478–93.
Article
CAS
PubMed
Google Scholar
Izumi H, Tsuda M, Sato Y, Kosaka N, Ochiya T, Iwamoto H, et al. Bovine milk exosomes contain microRNA and mRNA and are taken up by human macrophages. J Dairy Sci. 2015;98(5):2920–33.
Article
CAS
PubMed
Google Scholar
Watson PE, Watson ID, Batt RD. Total body water volumes for adult males and females estimated from simple anthropometric measurements. Am J Clin Nutr. 1980;33(1):27–39.
Article
CAS
PubMed
Google Scholar
Balaj L, Atai NA, Chen W, Mu D, Tannous BA, Breakefield XO, et al. Heparin affinity purification of extracellular vesicles. Sci Rep. 2015;5:10266.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zempleni J, Mock DM. Mitogen-induced proliferation increases biotin uptake into human peripheral blood mononuclear cells. Am J Phys Cell Phys. 1999;276(5):C1079–84.
CAS
Google Scholar
Wang L, Sadri M, Giraud D, Zempleni J. RNase H2-dependent polymerase chain reaction and elimination of confounders in sample collection, storage, and analysis strengthen evidence that microRNAs in bovine milk are bioavailable in humans. J Nutr. 2018;148(1):153–9.
Article
PubMed
PubMed Central
Google Scholar
Heintz-Buschart A, Yusuf D, Kaysen A, Etheridge A, Fritz JV, May P, et al. Isolation of nucleic acids from low biomass samples: detection and removal of sRNA contaminants. BMC Biol. 2018;16:52.
Article
PubMed
PubMed Central
Google Scholar
American Academy of Pediatrics, section on breastfeeding. Breastfeeding and the use of human milk. Pediatrics. 2012;129(3):e827–e41.
Centers for Disease Control and Prevention. Breastfeeding among U.S. children born 2010–2017, CDC national immunization surveys [Internet]. 2019 [cited 12/09/2020]. Available from: http://www.cdc.gov/breastfeeding/data/nis_data/index.htm.
Centers for Disease Control and Prevention. Births and Natality Atlanta, GA2017 [Available from: https://www.cdc.gov/nchs/fastats/births.htm.
Andres A, Cleves MA, Bellando JB, Pivik RT, Casey PH, Badger TM. Developmental status of 1-year-old infants fed breast milk, cow's milk formula, or soy formula. Pediatrics. 2012;129(6):1134–40.
Article
PubMed
Google Scholar
Ong KK, Loos RJ. Rapid infancy weight gain and subsequent obesity: systematic reviews and hopeful suggestions. Acta Paediatr. 2006;95(8):904–8.
Article
PubMed
Google Scholar
Huang J, Zhang Z, Wu Y, Wang Y, Wang J, Zhou L, et al. Early feeding of larger volumes of formula milk is associated with greater body weight or overweight in later infancy. Nutr J. 2018;17(1):12.
Article
PubMed
PubMed Central
Google Scholar
Karaolis-Danckert N, Gunther AL, Kroke A, Hornberg C, Buyken AE. How early dietary factors modify the effect of rapid weight gain in infancy on subsequent body-composition development in term children whose birth weight was appropriate for gestational age. Am J Clin Nutr. 2007;86(6):1700–8.
Article
CAS
PubMed
Google Scholar
Chomtho S, Wells JC, Williams JE, Davies PS, Lucas A, Fewtrell MS. Infant growth and later body composition: evidence from the 4-component model. Am J Clin Nutr. 2008;87(6):1776–84.
Article
CAS
PubMed
Google Scholar
Owen CG, Martin RM, Whincup PH, Smith GD, Cook DG. Does breastfeeding influence risk of type 2 diabetes in later life? A quantitative analysis of published evidence. Am J Clin Nutr. 2006;84(5):1043–54.
Article
CAS
PubMed
Google Scholar
Singhal A. Early nutrition and long-term cardiovascular health. Nutr Rev. 2006;64(5 Pt 2):S44–9 discussion S72–91.
Article
PubMed
Google Scholar